[HTML][HTML] Hepatotoxic pyrrolizidine alkaloids induce DNA damage response in rat liver in a 28-day feeding study
J Ebmeyer, JD Rasinger, JG Hengstler… - Archives of …, 2020 - Springer
Pyrrolizidine alkaloids (PA) are secondary plant metabolites that occur as food and feed
contaminants. Acute and subacute PA poisoning can lead to severe liver damage in humans …
contaminants. Acute and subacute PA poisoning can lead to severe liver damage in humans …
Disturbance of gene expression in primary human hepatocytes by hepatotoxic pyrrolizidine alkaloids: A whole genome transcriptome analysis
C Luckert, S Hessel, D Lenze, A Lampen - Toxicology in vitro, 2015 - Elsevier
unsaturated pyrrolizidine alkaloids (PA) are plant metabolites predominantly occurring in the
plant families Asteraceae and Boraginaceae. Acute and chronic PA poisoning causes …
plant families Asteraceae and Boraginaceae. Acute and chronic PA poisoning causes …
Structure-dependent hepato-cytotoxic potencies of selected pyrrolizidine alkaloids in primary rat hepatocyte culture
L Gao, L Rutz, D Schrenk - Food and Chemical Toxicology, 2020 - Elsevier
Contamination of food, feed and herbal medicines with plants containing pyrrolizidine
alkaloids (PA) leads to measurable amounts of PA in many products. Since a number of PA …
alkaloids (PA) leads to measurable amounts of PA in many products. Since a number of PA …
Relative potency of fifteen pyrrolizidine alkaloids to induce DNA damage as measured by micronucleus induction in HepaRG human liver cells
A Allemang, C Mahony, C Lester, S Pfuhler - Food and chemical toxicology, 2018 - Elsevier
Abstract Plant-based 1, 2-unsaturated Pyrrolizidine Alkaloids (PAs) can be found as
contaminants in foods like teas, herbs and honey. PAs are responsible for liver genotoxicity …
contaminants in foods like teas, herbs and honey. PAs are responsible for liver genotoxicity …
Structure-dependent induction of apoptosis by hepatotoxic pyrrolizidine alkaloids in the human hepatoma cell line HepaRG: Single versus repeated exposure
J Waizenegger, A Braeuning, M Templin… - Food and Chemical …, 2018 - Elsevier
Pyrrolizidine alkaloids (PA) are secondary plant compounds. PA intoxication in humans
causes severe acute and chronic hepatotoxicity. However, the molecular mechanisms of PA …
causes severe acute and chronic hepatotoxicity. However, the molecular mechanisms of PA …
Intrinsic relative potency of a series of pyrrolizidine alkaloids characterized by rate and extent of metabolism
C Lester, J Troutman, C Obringer, K Wehmeyer… - Food and Chemical …, 2019 - Elsevier
Unsaturated pyrrolizidine alkaloids (PAs) are sometimes present in foods or herbal
supplements/medicines as impurities and pose potential concerns for liver genotoxicity …
supplements/medicines as impurities and pose potential concerns for liver genotoxicity …
[HTML][HTML] Pyrrolizidine alkaloid-induced transcriptomic changes in rat lungs in a 28-day subacute feeding study
J Buchmueller, H Sprenger, J Ebmeyer… - Archives of …, 2021 - Springer
Pyrrolizidine alkaloids (PAs) are secondary plant metabolites synthesized by a wide range
of plants as protection against herbivores. These toxins are found worldwide and pose a …
of plants as protection against herbivores. These toxins are found worldwide and pose a …
[HTML][HTML] The chemical structure impairs the intensity of genotoxic effects promoted by 1, 2-unsaturated pyrrolizidine alkaloids in vitro
J Buchmueller, AM Enge, A Peters, J Ebmeyer… - Food and Chemical …, 2022 - Elsevier
unsaturated pyrrolizidine alkaloids (PAs) represent a large group of secondary plant
metabolites exhibiting hepatotoxic, genotoxic, and carcinogenic properties upon …
metabolites exhibiting hepatotoxic, genotoxic, and carcinogenic properties upon …
Effects of glutathione and cysteine on pyrrolizidine alkaloid-induced hepatotoxicity and DNA adduct formation in rat primary hepatocytes
Pyrrolizidine alkaloids (PAs) are hepatotoxic, genotoxic, and carcinogenic phytochemicals.
Upon metabolic activation, PAs produce dehydropyrrolizidine alkaloids (dehydro-PAs) as …
Upon metabolic activation, PAs produce dehydropyrrolizidine alkaloids (dehydro-PAs) as …
Characterization of liver injury induced by a pyrrolizidine alkaloid in rats
Abstract Background Pyrrolizidine alkaloids (PAs) are common phytotoxins. PA intoxication
is reported to cause severe acute liver damage, typically known as hepatic sinusoidal …
is reported to cause severe acute liver damage, typically known as hepatic sinusoidal …