Creation of synthetic structures with an enzyme-like mechanism and turnover remains a
significant challenge. In this study, peptides containing a cysteine thiol and histidine …

While considerable attempts have been made to recreate the high turnover rates of enzymes
using synthetic enzyme mimics, most have failed and only a few have produced minimal …

Peptides respresent intriguing materials to achieve sustainable catalytic reactivity that mimic
the natural functions of enzymes, but without the limitations of temperature/solvent …

This thesis describes the development of iterative and combinatorial methods for identifying
small peptide scaffolds able to support catalytic function. The incorporation of thiamine …

The properties of synthetic peptides, including potency, stability, and bioavailability, are
strongly influenced by modification of the peptide chain termini. Unfortunately, generally …

The stability of pseudopeptides bearing sulfoximines as chiral backbone modifying element
towards proteinase K - ScienceDirect Skip to main contentSkip to article Elsevier logo …

Thioamide substitutions of the peptide backbone have been shown to reduce proteolytic
degradation, and this property can be used to generate competitive protease inhibitors and …

Proteins incorporating artificial moieties such as fluorophores and drugs have enjoyed
increasing use in chemical biology and drug development research. Preparation of such …

The concept of substrate mimetic strategy represents a new powerful method in the field of
enzymatic peptide synthesis. This strategy takes advantage of the shift in thesite‐specific …

Substrate mimetics are excellent tools for protease‐mediated peptide synthesis that enable
the coupling of peptides independently of the primary specificity of the enzyme without …