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The substrate mimetics approach is a versatile method for small‐scale enzymatic peptide‐
bond synthesis in aqueous systems. The protease‐recognized amino acid side chain is …

Although proteases are capable of synthesizing peptide bonds via the reverse of proteolysis,
they are not proficient at peptide fragment ligation. Further manipulations are needed to shift …

Peptide amidases are enzymes that convert C-terminal amides of amino acids or peptide
into corresponding acids. We investigated amidases for making peptide esters from peptide …

This article reviews the latest developments in protease-catalyzed peptide synthesis
focusing on the use of substrate mimetics. The substrate mimetics approach takes …

DESIGN AND CONSTRUCTION OF BIOLOGICALLY ACTIVE PEPTIDES1 INCLUDING
ENZYMES Page 1 Pure & Appi. Chem., Vol. 56, No. 8, pp. 979—987, 1984. 0033—4545/84 …

This article reports on the design and characteristics of substrate mimetics in protease-
catalyzed reactions. Firstly, the basis of protease-catalyzed peptide synthesis and the …

Enzymes' machinery has been an inspiration for chemists. Peptides are vital players in the
origin of life, being ancestors of complex enzymes. Even short peptides that are simple in …

Chemoenzymatic peptide synthesis is a rapidly developing technology for cost effective
peptide production on a large scale. As an alternative to the traditional C→ N strategy, which …