Native chemical ligation is a key reaction in the toolbox of chemical methods for the
synthesis of native and modified proteins. The catalysis of ligation is commonly performed by …

In protein synthesis, peptide thioesters are frequently used as key building blocks for the
ligation strategy. We report herein on the synthesis of a peptide thioester using an N to S …

Enzyme‐specific activation and the substrate mimetics strategy are effective ways to
circumvent the limited substrate recognition often encountered in protease‐catalyzed …

This tutorial review outlines the modern ligation methods that enable the efficient total
chemical synthesis of enzymes and other protein molecules. Key to this success is the …

Total chemical synthesis of proteins has been rendered practical by the chemical ligation
principle: chemoselective condensation of unprotected peptide segments equipped with …

In contrast to large proteins, small peptide catalysts typically display limited specificity for
small molecule substrates. This is presumably a result of the limited opportunities small …

Abstract This Focus Review describes the evolution of artificial proteases, which are
synthetic catalysts for peptide hydrolysis that mimic the action of natural proteases. The …

Identification of substrate-analog trypsin inhibitors through the screening of synthetic
peptide combinatorial libraries Page 1 Biochemistry 1993, 32, 11035-11041 11035 …

Methyl esters of protected peptides (X-protected peptide-OMe) are synthetic precursors of
enzyme substrates and inhibitors, as well as of acyl donors employed in chemical and …