[HTML][HTML] Exploiting cannabinoid-induced cytotoxic autophagy to drive melanoma cell death

JL Armstrong, DS Hill, CS McKee… - Journal of Investigative …, 2015 - Elsevier
Although the global incidence of cutaneous melanoma is increasing, survival rates for
patients with metastatic disease remain< 10%. Novel treatment strategies are therefore …

[HTML][HTML] Cannabinoid action induces autophagy-mediated cell death through stimulation of ER stress in human glioma cells

M Salazar, A Carracedo, ÍJ Salanueva… - The Journal of …, 2009 - Am Soc Clin Investig
Autophagy can promote cell survival or cell death, but the molecular basis underlying its
dual role in cancer remains obscure. Here we demonstrate that Δ 9-tetrahydrocannabinol …

[HTML][HTML] Molecular mechanism of autophagy and its regulation by cannabinoids in cancer

XC Lee, E Werner, M Falasca - Cancers, 2021 - mdpi.com
Simple Summary This review examines the complex function of autophagy in malignancy
and explores its regulation by cannabinoids in different cancers. Autophagy is an important …

[HTML][HTML] Cannabinoid-associated cell death mechanisms in tumor models

G Calvaruso, O Pellerito… - … journal of oncology, 2012 - spandidos-publications.com
In recent years, cannabinoids (the active components of Cannabis sativa) and their
derivatives have received considerable interest due to findings that they can affect the …

[HTML][HTML] Roles of cannabinoids in melanoma: Evidence from in vivo studies

A Bachari, TJ Piva, SA Salami, N Jamshidi… - International Journal of …, 2020 - mdpi.com
Melanoma is the fourth most common type of cancer diagnosed in Australians after breast,
prostate, and colorectal cancers. While there has been substantial progress in the treatment …

Critical appraisal of the potential use of cannabinoids in cancer management

BJ Cridge, RJ Rosengren - Cancer management and research, 2013 - Taylor & Francis
Cannabinoids have been attracting a great deal of interest as potential anticancer agents.
Originally derived from the plant Cannabis sativa, there are now a number of endo-, phyto …

Cannabidiol induces programmed cell death in breast cancer cells by coordinating the cross-talk between apoptosis and autophagy

A Shrivastava, PM Kuzontkoski, JE Groopman… - Molecular cancer …, 2011 - AACR
Cannabidiol (CBD), a major nonpsychoactive constituent of cannabis, is considered an
antineoplastic agent on the basis of its in vitro and in vivo activity against tumor cells …

Cannabinoid receptors as novel targets for the treatment of melanoma

C Blázquez, A Carracedo, L Barrado… - The FASEB …, 2006 - Wiley Online Library
Melanoma causes the greatest number of skin cancer‐related deaths worldwide. Despite
intensive research, prevention and early detection are the only effective measures against …

Development of potent autophagy inhibitors that sensitize oncogenic BRAF V600E mutant melanoma tumor cells to vemurafenib

ML Goodall, T Wang, KR Martin, MG Kortus… - Autophagy, 2014 - Taylor & Francis
Autophagy is a dynamic cell survival mechanism by which a double-membrane vesicle, or
autophagosome, sequesters portions of the cytosol for delivery to the lysosome for recycling …

[HTML][HTML] The association of N-palmitoylethanolamine with the FAAH inhibitor URB597 impairs melanoma growth through a supra-additive action

L Hamtiaux, J Masquelier, GG Muccioli, C Bouzin… - BMC cancer, 2012 - Springer
Background The incidence of melanoma is considerably increasing worldwide. Frequent
failing of classical treatments led to development of novel therapeutic strategies aiming at …