To determine the cortical mechanism that underlies the cognitive impairment and motor
disability in hereditary spastic paraplegia (HSP), nine HSP patients from a Chinese family …

Objective: SPG4 is an autosomal dominant pure form of hereditary spastic paraplegia (HSP)
caused by mutations in the SPAST gene. HSP is considered an upper motor neuron …

Hereditary spastic paraplegias (HSP) are a group of clinically and genetically
heterogeneous disorders with the hallmark of progressive spastic gait disturbance. We used …

Hereditary spastic paraplegia (HSP) linked to the spastic gait gene 4 (SPG4) is
controversial, as the “pure” form traditionally has been considered confined to the long …

Background To analyze the clinical phenotype of hereditary spastic paraplegia (HSP)
caused by SPG11 mutations (SPG11-HSP). Methods Among the 17 patients with sporadic …

Background SPG11-linked hereditary spastic paraplegia is characterized by multisystem
neurodegeneration leading to a complex clinical and yet incurable phenotype of progressive …

Mutations in the SPG4 gene (SPG4-HSP) are the most frequent cause of hereditary spastic
paraplegia, but the extent of the neurodegeneration related to the disease is not yet known …

Background: Hereditary spastic paraplegia (HSP) is a clinically and genetically
heterogeneous neurodegenerative disorder characterized by progressive spastic …

BACKGROUND: Hereditary spastic paraplegia is a clinically and genetically heterogeneous
neurodegenerative disorder characterized by progressive spasticity of the lower limbs …

Abstract Spastic paraplegia type 4 (SPG4), caused by SPAST mutations, is the most
predominant subtype of hereditary spastic paraplegia. Most documented SPG4 patients …