To examine to what extent a receptor site differs from an acceptor site, it may be helpful to try
to define the receptor concept. Fig. 1 shows schematically that the difference essentially …

In receptor binding studies, it is important to understand the scope and limitations of both the
technique and the results obtained by its application. This article considers some of the …

Studies of the binding of ligands to various putative pharmacologic receptors are entering a
new phase. Over the past decade, sufficient expertise has been developed to measure with …

The study of binding is not an easy task especially because of the difficulty of interpreting the
results in terms of binding on specific receptor sites. The problem is not new; what is new is …

The rapid advance in the understanding of the receptor mediated mechanisms, whereby a
variety of drugs, hormones and toxins act at the cell membrane, can be attributed in large …

In ligand binding studies, it is often difficult to apply kinetic analyses because of an
uncertainty in experimental data obtained at high ligand concentrations. Under such …

In an interview'published in 1974, Sir Robert Robinson, questioned about the future
direction of organic chemistry, replied that he thought that among areas which would …

It is common practice to interpret the effect of a given drug on a given effector system in
terms of an interaction between the drug and a specific receptive substance or receptor of …

Receptors transduce binding (molecular recognition) to a response. Binding methodology
provides a simple means of rapidly screening drugs for possible activity on a multitude of …

One of the major advances in the understanding of the mechanism of action of hormones,
neurotransmitters and drugs had arisen from the hypothesis that the physiological or …