Diabetes is a chronic and incurable disease, which results from absolute or relative insulin
insufficiency. Therefore, pancreatic beta cells, which are the only type of cell that expresses …

Aims/hypothesis While pancreatic beta cells have been shown to originate from endocrine
progenitors in ductal regions, it remains unclear precisely where beta cells emerge from and …

Understanding in detail how pancreatic endocrine cells develop is important for many
reasons. From a scientific point of view, elucidation of such a complex process is a major …

In diabetes mellitus, insulin-producing beta cells in the pancreas are lost (type 1) or
dysfunctional (type 2). Cell replacement therapy has emerged as a promising alternative to …

Aims/hypothesis Glucagon-expressing pancreatic alpha cells have attracted much attention
for their plasticity to transdifferentiate into insulin-producing beta cells; however, it remains …

Pancreatic β and α cells play essential roles in maintaining glucose homeostasis. However,
the mechanisms by which these distinct cell populations are generated, expand, and mature …

Type 1 diabetes is a metabolic disease resulting in the selective loss of pancreatic insulin-
producing β-cells and affecting millions of people worldwide. The side effects of diabetes are …

Decoding the molecular composition of individual Ngn3+ endocrine progenitors (EPs)
during pancreatic morphogenesis could provide insight into the mechanisms regulating …

Understanding how pancreatic β cells achieve and maintain functional identity as insulin-
secreting cells is a major roadblock in our understanding of the aetiology of diabetes …

In the developing embryo, appropriate patterning of the endoderm fated to become
pancreas requires the spatial and temporal coordination of soluble factors secreted by the …