In the search of new symmetrical derivatives with anticancer activity, we have looked for
novel compounds able to induce a selective proapoptotic mechanism in cancer cells. The …

In the present study, we investigated the effect of a novel 3-arylisoquinoline derivative 3-(6-
ethyl-benzo [1, 3] dioxol-5-yl)-7, 8-dimethoxy-2-methyl-2H-isoquinolin-1-one (CWJ-081) on …

The anti-carcinogenic effect of the new quinazolinone compound, named MMD, was tested
on MCF-7 human breast cancer cell line. The synthesis of quinazolinone-based compounds …

Nitrogen-rich heterocyclic compounds represent a unique class of chemicals with especial
properties and have been modified to design novel pharmaceutically active compounds. In …

The synthesis of new 3-cyano-2-substituted pyridines bearing various pharmacophores and
functionalities at position 2 is described. The synthesized compounds were evaluated for …

Quinoline-based structures possess various types of biological activities and recently have
attracted attention as an antitumor scaffold via different known anti-cancer mechanisms. In …

Two new synthesized and characterized quinazoline Schiff bases 1 and 2 were investigated
for anticancer activity against MCF-7 human breast cancer cell line. Compounds 1 and 2 …

The aim of the present study is to synthesise an aryl ester compound from quinoline-2-
carboxylic acid to evaluate its apoptotic, cell cycle blockade, and antiproliferative activity on …

A novel series of 2-arylquinazolinones 7a-o bearing trans-stilbene moiety were designed,
synthesized, and evaluated against human breast cancer cell lines including human breast …

1-Benzoyl-3-cyanopyrrolo [1, 2-a] quinoline (2a) was identified as a novel apoptosis inducer
through our caspase-and cell-based high-throughput screening assay. Compound 2a had …