In order to show antiproliferation and cancerous cell growth inhibition of quinazoline
derivatives, a series of 2-(chloromethyl)-3-phenylquinazolin-4 (3H)-ones (H 1–H 11) were …

The objective of this study is to investigate the antiproliferative and cytotoxic properties and
the action mechanism of substituted quinoline and tetrahydroquinolines 3, 4, 5, 7, and 8 …

Pancreatic cancer is one of the most devastating of all malignancies with poor prognosis
and high mortality rates worldwide. Thymoquinone, plumbagin and juglone, which are …

The in vitro cytotoxicity of some substituted quinazolinones, 1–15, was evaluated using NCI
(10 µM) in a full NCI 59–cell line panel assay. Relative to the reference drug, imatinib (PCE …

A series of novel triazole linked N-(pyrimidin-2yl) benzo [d] thiazol-2-amine 5a–k were
synthesized and evaluated for anticancer activity against breast (MCF-7), lung (A549) and …

New phenyl and thiophene dispiro indeno quinoxaline pyrrolidine quinolone analogues
were synthesized by a one-pot four-component [3+ 2] cycloaddition reaction between (E)-3 …

A series of novel quinazolinone derivatives bearing a disulfide bond were designed and
synthesized. Their in vitro antiproliferative activities were evaluated using CCK-8 assay …

Quinazolines are known to be multitarget agents with broad spectrum of biological activity.
Aim: To investigate anticancer activity of newly prepared 6-bromo-2-(morpholin-1-yl)-4 …

Two novel chemotherapeutic chalcones were synthesized and their structures were
confirmed by different spectral tools. Theoretical studies such as molecular modeling were …

A series of novel 4 (1H)-quinolone derivatives was synthesized and evaluated for
antiproliferative activity in vitro. The results showed that these compounds exhibited more …