Loss of cystic fibrosis transmembrane conductance regulator (CFTR) function reduces
chloride secretion and increases sodium uptake, but it is not clear why CFTR mutation also …

The role of cystic fibrosis (CF) transmembrane conductance regulator (CFTR) in airway
epithelial wound repair was investigated using normal human bronchial epithelial (NHBE) …

Cystic fibrosis (CF) is an autosomal recessive, life-threatening condition affecting many
organs and tissues, the lung disease being the chief cause of morbidity and mortality …

Airway damage and remodelling are important components of lung pathology progression in
cystic fibrosis (CF). Although repair mechanisms are engaged to restore the epithelial …

Primary airway epithelial cells grown in air-liquid interface differentiate into cultures that
resemble native epithelium morphologically, express ion transport similar to those in vivo …

In cystic fibrosis (CF), a lack of functional CF transmembrane conductance regulator (CFTR)
chloride channels causes defective secretion by submucosal glands (SMGs), leading to …

Rationale The cystic fibrosis transmembrane conductance regulator (CFTR) and Calcium-
activated Chloride Conductance (CaCC) each play critical roles in maintaining normal …

Background Cystic fibrosis (CF)-related diabetes (CFRD) is associated with faster
pulmonary function decline. Thus, we evaluated the impact of hyperglycemia on airway …

Background: Loss of cystic fibrosis transmembrane conductance regulator (CFTR) function
in cystic fibrosis (CF) causes dysregulation of multiple ion channels, water channels, and …

The cystic fibrosis transmembrane conductance regulator (CFTR) is an anion channel
whose dysfunction causes cystic fibrosis (CF). The loss of CFTR function in pulmonary …