Camptothecin (CPT) has unique anti-tumor activities, and its analogs such as irinotecan and
topotecan are clinically used as anti-cancer drugs. Recently, CPT biosynthesis pathway is …

Camptothecin is a chemotherapeutic drug widely used to treat various cancers. Ophiorrhiza
pumila is an ideal plant model for the study of camptothecin production, with various …

The plant Ophiorrhiza pumila produces camptothecin (CPT), a kind of terpene indole
alkaloid (TIAs) that has been widely used in treatment of cancer. Tryptophan-arginine-lysine …

The limited bioavailability of plant-derived natural products with anticancer activity poses
major challenges to the pharmaceutical industry. An example of this is camptothecin, a …

Ophiorrhiza pumila, as a folk herb belonging to the Rubiaceae family, has become a
potential source of camptothecin (CPT), which is a monoterpenoid indole alkaloid with good …

Ophiorrhiza pumila (O. pumila; Op) is a medicinal herbaceous plant, which can accumulate
camptothecin (CPT). CPT and its derivatives are widely used as chemotherapeutic drugs for …

Camptothecin is a plant-derived alkaloid and important precursor of clinically used anti-
tumor drugs, but little is known about regulatory mechanism of camptothecin production in …

The hairy roots (HR) of Ophiorrhiza pumila produce camptothecin (CPT), a monoterpenoid
indole alkaloid used as a precursor in the synthesis of chemotherapeutic drugs. O. pumila …

Camptothecin (CPT) is a natural compound with remarkable antitumor activities due to its
special mechanism of inhibiting DNA topoisomerase I. Ophiorrhiza pumila was found to …

WRKY transcription factors, one of the largest families of transcriptional regulators in plants,
involve in multiple life activities including plant growth and development as well as stress …