Senescence drives organismal aging, yet the deep characterization of senescent cells in
vivo remains incomplete. Here, we apply mass cytometry by time-of-flight using carefully …

Although cellular senescence drives multiple age-related co-morbidities through the
senescence-associated secretory phenotype, in vivo senescent cell identification remains …

Cellular senescence refers to a process induced by various types of stress that causes
irreversible cell cycle arrest and distinct cellular alterations, including profound changes in …

Aging is associated with increased cellular senescence, which is hypothesized to drive the
eventual development of multiple comorbidities. Here we investigate a role for senescent …

Cellular senescence is a fundamental mechanism by which cells remain metabolically
active yet cease dividing and undergo distinct phenotypic alterations, including upregulation …

Physical function declines in old age, portending disability, increased health expenditures,
and mortality. Cellular senescence, leading to tissue dysfunction, may contribute to these …

Cellular senescence entails essentially irreversible replicative arrest, apoptosis resistance,
and frequently acquisition of a pro-inflammatory, tissue-destructive senescence-associated …

Cellular senescence is a state of irreversibly arrested proliferation, often induced by
genotoxic stress [1]. Senescent cells participate in a variety of physiological and pathological …

The development of genetic tools allowed for the validation of the pro-aging and pro-disease
functions of senescent cells in vivo. These discoveries prompted the development of …

The skeletal system contains a series of sophisticated cellular lineages arising from the
mesenchymal stem cells (MSCs) and hematopoietic stem cells (HSCs) that determine the …