Serum response factor (SRF) is a highly conserved and widely expressed, single copy
transcription factor that theoretically binds up to 1,216 permutations of a 10-base pair cis …

The immediate-early gene product and zinc finger transcription factor early growth response
(Egr)-1 plays a key master regulatory role in multiple cardiovascular pathological processes …

Activation of the transcription factor serum response factor (SRF) is dependent on Rho-
controlled changes in actin dynamics. We used pathway-specific inhibitors to compare the …

The transcription factor Egr‐1 functions as a key regulator in cellular growth, differentiation,
and apoptosis. The loss of Egr‐1 expression is closely associated with tumor development …

The early growth response gene product Egr-1 has been shown to have great impact on
growth, proliferation, and differentiation in a wide variety of cells, including T cells. In this …

Fibrosis is a deregulated and ultimately defective form of tissue repair that underlies a large
number of chronic human diseases, as well as obesity and aging. The pathogenesis of …

The transcription factor Egr-1 regulates the expression of numerous genes involved in
differentiation, growth, and in response to environmental signals. Egr-1 activity is modulated …

Publisher Summary This chapter discusses the early growth response protein (Egr) gene
family and its most extensively characterized member, Egr-1, first identified as an immediate …

The early growth response gene (Egr-1) codes for a zinc finger transcription factor that has
important roles in the regulation of cell growth, differentiation, and survival. Aberrant Egr-1 …

The transcription factor early growth response gene 1 (EGR1) has been implicated in
diverse roles in the regulation of cell growth, apoptosis, and differentiation. Previous studies …