CCR5 (CD195) is a receptor for the chemokines RANTES, MIP-1α, and MIP-1β and is used
by HIV-1 as a co-receptor for entry into macrophages and CD4+ T cells. CCR5 exists in …

CCR9 is as an interesting target for the treatment of human CCR9+-T cell acute
lymphoblastic leukemia, since its expression is limited to immature cells in the thymus …

Solid tumors are embedded in a stromal microenvironment consisting of immune cells, such
as macrophages and lymphocytes, as well as nonimmune cells, such as endothelial cells …

Human chemokine receptor 8 (CCR8) is a promising drug target for cancer and autoimmune
diseases immunotherapy. Monoclonal antibody-based CCR8 targeted treatment shows …

The 1990s brought a burst of information regarding the structure, expression pattern, and
role in leukocyte migration and adhesion of chemokines and their receptors. At that time, the …

The CC motif chemokine receptor 8 (CCR8) is a class A G-protein coupled receptor that has
emerged as a promising therapeutic target in cancer. Targeting CCR8 with an antibody has …

The chemokine receptor CCR2 is highly expressed on leukocytes in several inflammatory
diseases of both mice and men. Apart from blockade of CCR2 to prevent chemokine …

Human CC chemokine ligand 2 (CCL2), also known as monocyte chemoattractant protein-1
(MCP-1), is a member of the β chemokine family whose actions are mediated through the G …

The chemokines CCL17 (TARC) and CCL22 (MDC) function through the same receptor,
CCR4, but have been proposed to differentially affect the immune response. To better …

Relapsed or refractory T acute lymphoblastic leukemia (T-ALL) still carries poor prognosis.
Aiming to improve outcomes, the therapeutic potential of an anti-CCR9 monoclonal antibody …