CC chemokines (or β-chemokines) are 28 chemotactic cytokines with an N-terminal CC
domain that play an important role in immune system cells, such as CD4+ and CD8+ …

Although regulatory T cells (Treg) are inhibitory immune cells that are essential for
maintaining immune homeostasis, Tregs that infiltrate tumor tissue promote tumor growth by …

Chemokines are small proteins, that regulate cell migration in many physiological and
pathologic processes in human body. They are also responsible for cancer progression. CC …

The invention is directed an anti-CCR5 antibody which com prises (i) two light chains, each
light chain comprising the expression product of a plasmid designated pVK: HuPRO14O-VK …

The chemokine receptor CCR4 is preferentially expressed on certain immune cells and
some hematological tumor cells, which play pivotal roles in suppression of host immune …

The chemokine CCL2, which is best known for its chemotactic functions, is expressed not
only by immune cells, but also by several types of malignant and stromal cells. CCL2 has …

Bispecific antibodies are promising agents for immunotherapy. Here, we describe a
quadroma‐based trifunctional bispecific antibody binding the chemokine receptor CXCR5 …

The CC chemokine receptor 6 (CCR6) is a G protein-coupled receptor (GPCR) involved in a
wide range of biological processes. When CCR6 binds to its sole ligand CCL20, a signaling …

We previously described the in vitro characteristics of the potent and selective CCR1
antagonist, CP-481,715. In addition to being selective for CCR1 vs other chemokine …

Several recent studies have revealed important contributions of chemokines and their
receptors to the development and progression of both hematopoietic and nonhematopoietic …