The human CCL2 chemokine is implicated in many chronic inflammatory conditions. In the
mouse, there are two CCL2 homologues, CCL2 (MCP-1/JE) and CCL12 (MCP-5). Both are …

The homeostatic chemokine CCL17, also known as thymus and activation regulated
chemokine (TARC), has been associated with various diseases such as asthma, idiopathic …

CCL21 is a human chemokine that recruits normal immune cells and metastasizing tumor
cells to lymph nodes through activation of the G protein-coupled receptor CCR7. The CCL21 …

Background CC-family chemokine receptor 2 (CCR2) is implicated in the trafficking of blood-
borne monocytes to sites of inflammation and is implicated in the pathogenesis of several …

The CC chemokine receptor-1 (CCR1) is a prime therapeutic target for treating autoimmune
diseases. Through high capacity screening followed by chemical optimization, we identified …

A recombinant antibody or the antibody fragment thereof which specifically reacts with an
extracellular domain of human CCR4; a DNA which encodes the recombinant antibody or …

Chemokines are key molecules that drive migration of lymphoid and myeloid cells toward
organs in basal as well as inflammatory conditions. By recruiting immature dendritic cells to …

The chemokine receptors CCR2 and CCR5 play important roles in the recruitment of
monocytes/macrophages and T cells. To better understand the role of both receptors in …

Chemokines are a family of low-molecular weight proteins that mediate their effects through
binding with chemokine receptors (a group of seven trans-membrane spanning G-protein …

Background: Development of functional monoclonal antibodies against intractable GPCR
targets. Results: Identification of structured peptides mimicking the ligand binding site, their …