Generation, characterization and biological activity of CCL2 (MCP-1/JE) and CCL12 (MCP-5) specific antibodies
P Tsui, A Das, B Whitaker, M Tornetta… - Human …, 2007 - content.iospress.com
The human CCL2 chemokine is implicated in many chronic inflammatory conditions. In the
mouse, there are two CCL2 homologues, CCL2 (MCP-1/JE) and CCL12 (MCP-5). Both are …
mouse, there are two CCL2 homologues, CCL2 (MCP-1/JE) and CCL12 (MCP-5). Both are …
Structural insights into chemokine CCL17 recognition by antibody M116
A Teplyakov, G Obmolova, GL Gilliland - Biochemistry and Biophysics …, 2018 - Elsevier
The homeostatic chemokine CCL17, also known as thymus and activation regulated
chemokine (TARC), has been associated with various diseases such as asthma, idiopathic …
chemokine (TARC), has been associated with various diseases such as asthma, idiopathic …
Solution structure of CCL21 and identification of a putative CCR7 binding site
M Love, JL Sandberg, JJ Ziarek, KP Gerarden… - Biochemistry, 2012 - ACS Publications
CCL21 is a human chemokine that recruits normal immune cells and metastasizing tumor
cells to lymph nodes through activation of the G protein-coupled receptor CCR7. The CCL21 …
cells to lymph nodes through activation of the G protein-coupled receptor CCR7. The CCL21 …
Cloning and functional characterization of the rabbit CC chemokine receptor 2
D Lu, X Yuan, RJ Evans, AT Pappas, H Wang, EW Su… - BMC immunology, 2005 - Springer
Background CC-family chemokine receptor 2 (CCR2) is implicated in the trafficking of blood-
borne monocytes to sites of inflammation and is implicated in the pathogenesis of several …
borne monocytes to sites of inflammation and is implicated in the pathogenesis of several …
Identification and characterization of a potent, selective, and orally active antagonist of the CC chemokine receptor-1
M Liang, C Mallari, M Rosser, HP Ng, K May… - Journal of Biological …, 2000 - ASBMB
The CC chemokine receptor-1 (CCR1) is a prime therapeutic target for treating autoimmune
diseases. Through high capacity screening followed by chemical optimization, we identified …
diseases. Through high capacity screening followed by chemical optimization, we identified …
Recombinant antibody and antibody fragment
K Shitara, N Hanai, E Shoji, M Sakurada… - US Patent …, 2006 - Google Patents
A recombinant antibody or the antibody fragment thereof which specifically reacts with an
extracellular domain of human CCR4; a DNA which encodes the recombinant antibody or …
extracellular domain of human CCR4; a DNA which encodes the recombinant antibody or …
Cloning, expression and functional characterization of chicken CCR6 and its ligand CCL20
I Munoz, M Berges, C Bonsergent, F Cormier-Aline… - Molecular …, 2009 - Elsevier
Chemokines are key molecules that drive migration of lymphoid and myeloid cells toward
organs in basal as well as inflammatory conditions. By recruiting immature dendritic cells to …
organs in basal as well as inflammatory conditions. By recruiting immature dendritic cells to …
Expression and characterization of the chemokine receptors CCR2 and CCR5 in mice
M Mack, J Cihak, C Simonis, B Luckow… - The Journal of …, 2001 - journals.aai.org
The chemokine receptors CCR2 and CCR5 play important roles in the recruitment of
monocytes/macrophages and T cells. To better understand the role of both receptors in …
monocytes/macrophages and T cells. To better understand the role of both receptors in …
[HTML][HTML] The role of chemokines and their receptors in non-Hodgkin's lymphoma
M Bryson - 2011 - theses.gla.ac.uk
Chemokines are a family of low-molecular weight proteins that mediate their effects through
binding with chemokine receptors (a group of seven trans-membrane spanning G-protein …
binding with chemokine receptors (a group of seven trans-membrane spanning G-protein …
A combination of in vitro techniques for efficient discovery of functional monoclonal antibodies against human CXC chemokine receptor-2 (CXCR2)
RS Boshuizen, C Marsden, J Turkstra, CJ Rossant… - MAbs, 2014 - Taylor & Francis
Background: Development of functional monoclonal antibodies against intractable GPCR
targets. Results: Identification of structured peptides mimicking the ligand binding site, their …
targets. Results: Identification of structured peptides mimicking the ligand binding site, their …