Renal fibrosis is an irreversible and progressive process that causes severe dysfunction in
chronic kidney disease (CKD). The progression of CKD stages is highly associated with a …

Klotho is a protein primarily expressed in renal tubular epithelial cells. Studies have
suggested that Klotho is an antiaging protein that reduces renal fibrosis after acute kidney …

Chronic kidney disease (CKD) and acute kidney injury (AKI) are public health problems, and
their prevalence rates have increased with the aging of the population. They are associated …

Background Klotho is a multifunctional protein, which exists both in a membrane bound and
a soluble form. In renal tubules, Klotho is involved in cell senescence, anti-oxidant response …

Background Studies have shown that the Klotho gene has tremendous potential for future
therapeutic purposes in both acute and chronic kidney diseases (CKD). This study aimed to …

Klotho Regulates Epithelial-to-Mesenchymal Transition In Vitro via Wnt/β-Catenin Pathway
and Attenuates Chronic Allograft Dysfunction in a Rat Renal Transplant Model - PMC Back to …

Renal expression of the klotho gene is markedly suppressed in chronic kidney disease
(CKD). Since renal fibrosis is the final common pathology of CKD, we tested whether …

Purpose Klotho deficiency is implicated in various kidney diseases, including renal fibrosis.
The aim of this study was to investigate the effect of Klotho administration on epithelial …

Introduction: While recent investigations show that klotho exerts renoprotective actions, it
has not been fully addressed whether klotho protein supplementation reverses renal …

Acute Kidney Injury (AKI) and Chronic Kidney Disease (CKD) are a growing public health
problem. There is a paucity of sensitive biomarkers to detect AKI, early CKD, and ameliorate …