Src is required for migration, phagocytosis, and interferon beta production in Toll-like receptor-engaged macrophages
MC Maa, TH Leu - Biomedicine, 2016 - Springer
As an evolutionarily conserved mechanism, innate immunity controls self-nonself
discrimination to protect a host from invasive pathogens. Macrophages are major …
discrimination to protect a host from invasive pathogens. Macrophages are major …
The inducible nitric-oxide synthase (iNOS)/Src axis mediates Toll-like receptor 3 tyrosine 759 phosphorylation and enhances its signal transduction, leading to …
MY Hsieh, MY Chang, YJ Chen, YK Li… - Journal of Biological …, 2014 - ASBMB
Double-stranded RNA (dsRNA) induces phosphorylation of Toll-like receptor 3 (TLR3) at
tyrosine 759 and subsequently triggers signaling pathways to promote interferon-β (IFN-β) …
tyrosine 759 and subsequently triggers signaling pathways to promote interferon-β (IFN-β) …
Activation of Toll-like receptors induces macrophage migration via the iNOS/Src/FAK pathway
MC Maa, TH Leu - BioMedicine, 2011 - Elsevier
Macrophage motility is crucial in innate immunity. Toll-like receptors (TLRs), members of the
interleukin-1 receptor superfamily, are a family of transmembrane pattern recognition …
interleukin-1 receptor superfamily, are a family of transmembrane pattern recognition …
[HTML][HTML] The iNOS/Src/FAK axis is critical in Toll-like receptor-mediated cell motility in macrophages
MC Maa, MY Chang, J Li, YY Li, MY Hsieh… - … et Biophysica Acta (BBA …, 2011 - Elsevier
The Toll-like receptors (TLRs) play a pivotal role in innate immunity for the detection of
highly conserved, pathogen-expressed molecules. Previously, we demonstrated that …
highly conserved, pathogen-expressed molecules. Previously, we demonstrated that …
Is targeting Toll‐like receptors and their signaling pathway a useful therapeutic approach to modulating cytokine‐driven inflammation?
E Andreakos, B Foxwell, M Feldmann - Immunological reviews, 2004 - Wiley Online Library
Cytokine‐driven inflammation and tissue destruction is a common theme of chronic
inflammatory diseases such as rheumatoid arthritis, Crohn's disease, ulcerative colitis …
inflammatory diseases such as rheumatoid arthritis, Crohn's disease, ulcerative colitis …
Src family kinase tyrosine phosphorylates Toll-like receptor 4 to dissociate MyD88 and Mal/Tirap, suppressing LPS-induced inflammatory responses
J Mitchell, SJ Kim, A Seelmann, B Veit… - Biochemical …, 2018 - Elsevier
Src family kinases (SFKs) are a family of protein tyrosine kinases containing nine members:
Src, Lyn, Fgr, Hck, Lck, Fyn, Blk, Yes, and Ylk. Although SFK activation is a major immediate …
Src, Lyn, Fgr, Hck, Lck, Fyn, Blk, Yes, and Ylk. Although SFK activation is a major immediate …
Activation of c-Src: a hub for exogenous pro-oxidant-mediated activation of Toll-like receptor 4 signaling
To study the role of c-Src kinase in pro-oxidant-induced stimulation of Toll-like receptor 4
(TLR4), we used lipopolysaccharide from Escherichia coli K12 (LPS-EK) and …
(TLR4), we used lipopolysaccharide from Escherichia coli K12 (LPS-EK) and …
SCIMP is a universal Toll-like receptor adaptor in macrophages
In innate immune cells, pathogens and danger signals activate TLRs, unleashing potent and
tailored inflammatory responses. Previously, we reported that an immune-specific …
tailored inflammatory responses. Previously, we reported that an immune-specific …
A phospho-tyrosine–based signaling module using SPOP, CSK, and LYN controls TLR-induced IRF activity
K Tawaratsumida, V Redecke, R Wu, J Kuriakose… - Science …, 2022 - science.org
Toll-like receptors (TLRs) recognize pathogen-and host-derived factors and control immune
responses via the adaptor protein MyD88 and members of the interferon regulatory …
responses via the adaptor protein MyD88 and members of the interferon regulatory …
Revolutionizing medicine with toll-like receptors: A path to strengthening cellular immunity
JA Malik, G Kaur, JN Agrewala - International Journal of Biological …, 2023 - Elsevier
Toll-like receptors play a vital role in cell-mediated immunity, which is crucial for the immune
system's defense against pathogens and maintenance of homeostasis. The interaction …
system's defense against pathogens and maintenance of homeostasis. The interaction …