The development of the passive transdermal therapeutic system (TTS) as an effective
method of drug delivery has allowed the potent, lipid soluble opioid fentanyl to be …

Fentanyl is a synthetic opioid with short-acting analgesic activity after intravenous or
subcutaneous administration. The low molecular weight, high potency and lipid solubility of …

Fentanyl is a synthetic opioid agonist which interacts primarily with the μ-opioid receptor.
The low molecular weight, high potency and lipid solubility of fentanyl make it suitable for …

The high efficacy, low molecular weight and high lipid solubility of fentanyl make it a suitable
agent for transdermal administration. Effective plasma concentrations are maintained for up …

The transdermal route of drug delivery has been used for the effective administration of
therapeutic agents for more than a decade. The most important consideration in selecting a …

Transdermal delivery allows continuous systemic application of opioids through the intact
skin. This review analyses the pharmacokinetic properties of transdermal opioid …

A prospective phase II study was conducted to define the analgesic efficacy, acceptability
and toxicity of the transdermal therapeutic system (TTS) of fentanyl in Chinese patients with …

We performed an open-label pilot study to define analgesic efficacy, acceptability, and
toxicity of transdermal fentanyl in an ambulatory population of patients with cancer pain. Our …

The first clinical experience in the United States of the transdermal therapeutic system (TTS)
for delivery of fentanyl in cancer pain was a small study of five patients. Pain relief was …

OBJECTIVE: To review the use of transdermal fentanyl for the treatment of moderate to
severe chronic pain. The article provides background on the pharmacology and …