It is well documented that PPARα and PPARβ/δ share overlapping functions in regulating
myocardial lipid metabolism. However, previous studies demonstrated that cardiomyocyte …

Rationale: Peroxisome proliferator-activated receptors (PPARs)(α, γ, and δ/β) are nuclear
hormone receptors and ligand-activated transcription factors that serve as key determinants …

Peroxisome proliferator-activated receptor δ (PPARδ) is an essential determinant of basal
myocardial fatty acid oxidation (FAO) and bioenergetics. We wished to determine whether …

Three forms of PPARs are expressed in the heart. In animal models, PPARγ agonist
treatment improves lipotoxic cardiomyopathy; however, PPARγ agonist treatment of humans …

Excess lipid accumulation in the heart is associated with decreased cardiac function in
humans and in animal models. The reasons are unclear, but this is generally believed to …

Peroxisome proliferator-activated receptor β/δ (PPARβ/δ) is an essential transcription factor
in myocardial metabolism. This study aims to investigate the effects of PPARβ/δ activation in …

While the roles of PPARα and PPARδ (β) in transcriptional regulation of myocardial lipid
metabolisms are well established, an essential role of PPARγ in regulating lipid …

Recent evidence has defined an important role for PPARα in the transcriptional control of
cardiac energy metabolism. To investigate the role of PPARα in the genesis of the metabolic …

Objectives Peroxisome proliferator-activated receptors (PPAR) α and β/δ are essential
transcriptional regulators of fatty acid oxidation in the heart. However, little is known about …

In the diabetic heart, chronic activation of the PPARα pathway drives excessive fatty acid
(FA) oxidation, lipid accumulation, reduced glucose utilization, and cardiomyopathy. The …