Cardiomyocyte‐Restricted Deletion of PPARβ/δ in PPARα‐Null Mice Causes Impaired Mitochondrial Biogenesis and Defense, but No Further Depression of …
J Liu, P Wang, L He, Y Li, J Luo, L Cheng… - PPAR …, 2011 - Wiley Online Library
It is well documented that PPARα and PPARβ/δ share overlapping functions in regulating
myocardial lipid metabolism. However, previous studies demonstrated that cardiomyocyte …
myocardial lipid metabolism. However, previous studies demonstrated that cardiomyocyte …
Peroxisome proliferator-activated receptor δ is an essential transcriptional regulator for mitochondrial protection and biogenesis in adult heart
Rationale: Peroxisome proliferator-activated receptors (PPARs)(α, γ, and δ/β) are nuclear
hormone receptors and ligand-activated transcription factors that serve as key determinants …
hormone receptors and ligand-activated transcription factors that serve as key determinants …
High-fat feeding in cardiomyocyte-restricted PPARδ knockout mice leads to cardiac overexpression of lipid metabolic genes but fails to rescue cardiac phenotypes
Y Li, L Cheng, Q Qin, J Liu, W Lo, LA Brako… - Journal of molecular and …, 2009 - Elsevier
Peroxisome proliferator-activated receptor δ (PPARδ) is an essential determinant of basal
myocardial fatty acid oxidation (FAO) and bioenergetics. We wished to determine whether …
myocardial fatty acid oxidation (FAO) and bioenergetics. We wished to determine whether …
Cardiomyocyte expression of PPARγ leads to cardiac dysfunction in mice
NH Son, TS Park, H Yamashita… - The Journal of …, 2007 - Am Soc Clin Investig
Three forms of PPARs are expressed in the heart. In animal models, PPARγ agonist
treatment improves lipotoxic cardiomyopathy; however, PPARγ agonist treatment of humans …
treatment improves lipotoxic cardiomyopathy; however, PPARγ agonist treatment of humans …
PPARγ-induced cardiolipotoxicity in mice is ameliorated by PPARα deficiency despite increases in fatty acid oxidation
NH Son, S Yu, J Tuinei, K Arai, H Hamai… - The Journal of …, 2010 - Am Soc Clin Investig
Excess lipid accumulation in the heart is associated with decreased cardiac function in
humans and in animal models. The reasons are unclear, but this is generally believed to …
humans and in animal models. The reasons are unclear, but this is generally believed to …
Peroxisome proliferator-activated receptor β/δ activation in adult hearts facilitates mitochondrial function and cardiac performance under pressure-overload condition
Peroxisome proliferator-activated receptor β/δ (PPARβ/δ) is an essential transcription factor
in myocardial metabolism. This study aims to investigate the effects of PPARβ/δ activation in …
in myocardial metabolism. This study aims to investigate the effects of PPARβ/δ activation in …
[HTML][HTML] Conditional PPARγ knockout from cardiomyocytes of adult mice impairs myocardial fatty acid utilization and cardiac function
While the roles of PPARα and PPARδ (β) in transcriptional regulation of myocardial lipid
metabolisms are well established, an essential role of PPARγ in regulating lipid …
metabolisms are well established, an essential role of PPARγ in regulating lipid …
The cardiac phenotype induced by PPARα overexpression mimics that caused by diabetes mellitus
BN Finck, JJ Lehman, TC Leone… - The Journal of …, 2002 - Am Soc Clin Investig
Recent evidence has defined an important role for PPARα in the transcriptional control of
cardiac energy metabolism. To investigate the role of PPARα in the genesis of the metabolic …
cardiac energy metabolism. To investigate the role of PPARα in the genesis of the metabolic …
Cardiac peroxisome proliferator-activated receptor δ is essential in protecting cardiomyocytes from oxidative damage
Objectives Peroxisome proliferator-activated receptors (PPAR) α and β/δ are essential
transcriptional regulators of fatty acid oxidation in the heart. However, little is known about …
transcriptional regulators of fatty acid oxidation in the heart. However, little is known about …
Nuclear receptors PPARβ/δ and PPARα direct distinct metabolic regulatory programs in the mouse heart
EM Burkart, N Sambandam, X Han… - The Journal of …, 2007 - Am Soc Clin Investig
In the diabetic heart, chronic activation of the PPARα pathway drives excessive fatty acid
(FA) oxidation, lipid accumulation, reduced glucose utilization, and cardiomyopathy. The …
(FA) oxidation, lipid accumulation, reduced glucose utilization, and cardiomyopathy. The …