The role of microglia in the pathobiology of neuropathic pain development: what do we know?
H Zhao, A Alam, Q Chen, M A. Eusman… - BJA: British Journal …, 2017 - academic.oup.com
Neuropathic pain, a maladaptive and chronic condition that can develop after a lesion or
disease affecting the somatosensory system, is characterized by allodynia, hyperalgesia …
disease affecting the somatosensory system, is characterized by allodynia, hyperalgesia …
Microglial modulation as a target for chronic pain: from the bench to the bedside and back
With a widespread opioid epidemic and profound biopsychosocial implications, chronic pain
is a multifaceted public health issue requiring urgent attention. The treatment of chronic pain …
is a multifaceted public health issue requiring urgent attention. The treatment of chronic pain …
[PDF][PDF] Activated microglia in nociception
HS Smith - Pain physician, 2010 - painphysicianjournal.com
Microglial cells appear to play a vital role in the initiation of certain neuropathic pain states.
In order to initiate neuropathic pain, microglia need to be activated. Microglia activation in …
In order to initiate neuropathic pain, microglia need to be activated. Microglia activation in …
The mechanisms of microgliosis and pain following peripheral nerve injury
M Calvo, DLH Bennett - Experimental neurology, 2012 - Elsevier
Microglia are the resident macrophages in the central nervous system (CNS). Any insult to
the CNS homeostasis will induce a rapid change in microglia morphology, gene expression …
the CNS homeostasis will induce a rapid change in microglia morphology, gene expression …
Microglia in neuropathic pain: cellular and molecular mechanisms and therapeutic potential
Acute nociceptive pain is a key defence system that enables the detection of danger signals
that threaten homeostasis and survival. However, chronic pain (such as the neuropathic …
that threaten homeostasis and survival. However, chronic pain (such as the neuropathic …
Neuron–glia crosstalk gets serious: role in pain hypersensitivity
K Ren, R Dubner - Current Opinion in Anesthesiology, 2008 - journals.lww.com
Evidence indicates that central glial activation depends on nerve inputs from the site of injury
and release of chemical mediators. Hematogenous immune cells may migrate to/infiltrate …
and release of chemical mediators. Hematogenous immune cells may migrate to/infiltrate …
Microglia-mediated regulation of neuropathic pain: molecular and cellular mechanisms
M Tsuda - Biological and Pharmaceutical Bulletin, 2019 - jstage.jst.go.jp
Pain is a defense system that responds rapidly to harmful internal and external stimuli
through the somatosensory neuronal pathway. However, damage to the nervous system …
through the somatosensory neuronal pathway. However, damage to the nervous system …
Neuroinflammation and the generation of neuropathic pain
A Ellis, DLH Bennett - British journal of anaesthesia, 2013 - academic.oup.com
Inflammation is the process by which an organism responds to tissue injury involving both
immune cell recruitment and mediator release. Diverse causes of neuropathic pain are …
immune cell recruitment and mediator release. Diverse causes of neuropathic pain are …
Microglial regulation of neuropathic pain
Neuropathic pain is a highly debilitating chronic pain state that is a consequence of nerve
injury or of diseases such as diabetes, cancer, infection, autoimmune disease, or trauma …
injury or of diseases such as diabetes, cancer, infection, autoimmune disease, or trauma …
Microglial diversity in neuropathic pain
Microglia play pivotal roles in controlling CNS functions in diverse physiological and
pathological contexts, including neuropathic pain, a chronic pain condition caused by …
pathological contexts, including neuropathic pain, a chronic pain condition caused by …