Accumulating evidence suggests that microglial cells in the spinal cord play an important
role in the development of neuropathic pain. However, it remains largely unknown how glia …

Millions of people worldwide suffer from neuropathic pain as a result of damage to or
dysfunction of the nervous system under various disease conditions. Development of …

The treatment of chronic inflammatory and neuropathic pain is a major concern, and the
need for new more effective analgesics with less adverse effects is immense. Traditionally …

Persistent maladaptive neuroplastic changes secondary to neurotrophic factors and
interactions between neurons and microglia may well explain the phenomenon. This article …

Neuropathic pain is a debilitating chronic pain and represents a major clinical challenge.
The molecular and cellular mechanisms underlying its development and maintenance are …

Purpose Although pain is an adaptive sensory experience necessary to prevent further
bodily harm, the transition from acute to chronic pain is not adaptive and results in the …

Glia have emerged as key contributors to pathological and chronic pain mechanisms. On
activation, both astrocytes and microglia respond to and release a number of signalling …

A growing body of evidence from both clinical and animal studies indicates that chronic
neuropathic pain is associated with comorbid affective disorders. Spinal cord microglial …

Activation of glial cells and neuro–glial interactions are emerging as key mechanisms
underlying chronic pain. Accumulating evidence has implicated 3 types of glial cells in the …

Microglia, the intrinsic macrophages of the central nervous system, have previously been
shown to be activated in the spinal cord in several rat mononeuropathy models. Activation of …