Background: DNA methylation is influenced by environmental factors and contributes to
adverse modification of cancer risk and clinicopathological features. Methods: A case …

The aim of the present study was to examine the association between plasma heavy metals
and the metabolome in patients with breast cancer (BC), and the association with cancer …

Backgrounds Breast cancer is a heterogeneous disease without clear pathogenesis and
effective primary prevention. The “anti-cancer” effects of several trace elements have …

Background: Global DNA hypomethylation may result in chromosomal instability and
oncogene activation, and as a surrogate of systemic methylation activity, may be associated …

Background In previous observational studies, food-derived antioxidant vitamins have been
suggested to be associated with breast cancer. However, the findings were inconsistent and …

Purpose To examine DNA methylation as a mechanism linking diet, physical activity, weight
status, and breast cancer risk. Methods Insufficiently active women of varying weight status …

Breast cancer is the second leading cause of cancer mortality among women. Given its
important role in DNA methylation and synthesis, one-carbon metabolism may affect breast …

Intrauterine and early life exposure to folic acid has significantly increased in North America
owing to folic acid fortification, widespread supplemental use, and periconceptional …

The relative importance of biochemical pathways has not been previously examined when
considering the influence of diet on breast cancer risk. To address this issue, we used …

Background Vitamin D has anticarcinogenic and immune-related properties and may protect
against some diseases, including breast cancer. Vitamin D affects gene transcription and …