There is increasing evidence from genetic, immunohistochemical, proteomic and
epidemiological studies as well as in model systems that complement activation has an …

Increasing evidence suggests that inflammatory and immune components in brain are
important in Alzheimer's disease (AD) and anti-inflammatory and immunotherapeutic …

There is a critical unmet need for reliable markers of disease and disease course in mild
cognitive impairment (MCI) and early Alzheimer's disease (AD). The growing appreciation of …

The spectrum of inflammatory diseases is nowadays considered to include diverse diseases
of the central nervous system (CNS). Current evidence suggests that syndromes such as …

The complement system is a critical element of the innate immune system recognizing and
killing, or targeting for destruction, otherwise pathogenic organisms. In addition to triggering …

The brain is considered to be an immune privileged site, because the blood–brain barrier
limits entry of blood borne cells and proteins into the central nervous system (CNS). As a …

Complement proteins are integral components of amyloid plaques and cerebral vascular
amyloid in Alzheimer brains. They can be found at the earliest stages of amyloid deposition …

Alzheimer's disease (AD) is an age-related neurodegenerative disease that affects
approximately 24 million people worldwide. A number of different risk factors have been …

Alzheimer's disease is a type of dementia characterized by problems with short-term
memory, cognition, and difficulties with activities of daily living. It is a progressive …

The emergence of complement as an important player in normal brain development and
pathological remodelling has come as a major surprise to most scientists working in …