The mechanistic (or mammalian) target of rapamycin (mTOR) and the adenosine
monophosphate-activated protein kinase (AMPK) regulate cell survival and metabolism in …

Adenosine monophosphate (AMP)-activated protein kinase (AMPK) is a major cellular
energy sensor that is activated by an increase in the AMP/adenosine triphosphate (ATP) …

Compelling evidence indicates that the mammalian target of rapamycin (mTOR) signaling
pathway is involved in cellular senescence, organismal aging and age-dependent diseases …

mTOR inhibition is beneficial in neurodegenerative disease models and its effects are often
attributable to the modulation of autophagy and anti-apoptosis. Here, we report a neglected …

Alzheimer's disease (AD) is the most prevalent form of dementia in the elderly population
and has worldwide impact. The etiology of the disease is complex and results from the …

The mammalian target of rapamycin (mTOR) is a key regulator of cell growth, autophagy,
translation, and survival. Dysregulation of mTOR signaling is associated with cancer …

The mechanistic target of rapamycin protein complex, mTORC1, has received attention in
recent years for its role in aging and neurodegenerative diseases, such as Alzheimer's …

The kinase mammalian target of rapamycin (mTOR) integrates signals triggered by energy,
stress, oxygen levels, and growth factors. It regulates ribosome biogenesis, mRNA …

Disorders of metabolism affect multiple systems throughout the body, but may have the
greatest impact on both central and peripheral nervous systems. Current available …

Mechanistic/mammalian target of rapamycin (mTOR) belongs to the phosphatidylinositol
kinase-related kinase (PIKK) family. mTOR signaling is required for the commencement of …