Hypoxia activates nucleus tractus solitarii neurons projecting to the paraventricular nucleus of the hypothalamus

TL King, CM Heesch, CG Clark… - American Journal of …, 2012 - journals.physiology.org
Peripheral chemoreceptor afferent information is sent to the nucleus tractus solitarii (nTS),
integrated, and relayed to other brain regions to alter cardiorespiratory function. The nTS …

Paraventricular nucleus projections to the nucleus tractus solitarii are essential for full expression of hypoxia‐induced peripheral chemoreflex responses

BC Ruyle, L Lima‐Silveira, D Martinez… - The Journal of …, 2023 - Wiley Online Library
The hypothalamic paraventricular nucleus (PVN) is essential to peripheral chemoreflex
neurocircuitry, but the specific efferent pathways utilized are not well defined. The PVN …

Hypoxia activates a neuropeptidergic pathway from the paraventricular nucleus of the hypothalamus to the nucleus tractus solitarii

BC Ruyle, PJ Klutho, CP Baines… - American Journal …, 2018 - journals.physiology.org
The paraventricular nucleus of the hypothalamus (PVN) contributes to both autonomic and
neuroendocrine function. PVN lesion or inhibition blunts cardiorespiratory responses to …

The PVN enhances cardiorespiratory responses to acute hypoxia via input to the nTS

BC Ruyle, D Martinez, CM Heesch… - American Journal …, 2019 - journals.physiology.org
Chemoreflex neurocircuitry includes the paraventricular nucleus (PVN), but the role of PVN
efferent projections to specific cardiorespiratory nuclei is unclear. We hypothesized that the …

Sensory afferent and hypoxia-mediated activation of nucleus tractus solitarius neurons that project to the rostral ventrolateral medulla

DD Kline, TL King, JR Austgen, CM Heesch… - Neuroscience, 2010 - Elsevier
The nucleus tractus solitarius (nTS) of the brainstem receives sensory afferent inputs,
processes that information, and sends projections to a variety of brain regions responsible …

Hypoxia-excited neurons in NTS send axonal projections to Kölliker-Fuse/parabrachial complex in dorsolateral pons

G Song, H Xu, H Wang, SM MacDonald, CS Poon - Neuroscience, 2011 - Elsevier
Hypoxic respiratory and cardiovascular responses in mammals are mediated by peripheral
chemoreceptor afferents which are relayed centrally via the solitary tract nucleus (NTS) in …

Acute systemic hypoxia activates hypothalamic paraventricular nucleus-projecting catecholaminergic neurons in the caudal ventrolateral medulla

TL King, DD Kline, BC Ruyle… - American Journal of …, 2013 - journals.physiology.org
Hypoxia activates catecholamine neurons in the caudal ventrolateral medulla (CVLM). The
hypothalamic paraventricular nucleus (PVN) modulates arterial chemoreflex responses and …

Chronic intermittent hypoxia affects integration of sensory input by neurons in the nucleus tractus solitarii

DD Kline - Respiratory physiology & neurobiology, 2010 - Elsevier
The autonomic nervous and respiratory systems, as well as their coupling, adapt over a wide
range of conditions. Chronic intermittent hypoxia (CIH) is a model for recurrent apneas and …

The nucleus of the solitary tract and the coordination of respiratory and sympathetic activities

DB Zoccal, WI Furuya, M Bassi, DSA Colombari… - Frontiers in …, 2014 - frontiersin.org
It is well known that breathing introduces rhythmical oscillations in the heart rate and arterial
pressure levels. Sympathetic oscillations coupled to the respiratory activity have been …

Chronic sustained hypoxia enhances both evoked EPSCs and norepinephrine inhibition of glutamatergic afferent inputs in the nucleus of the solitary tract

W Zhang, FR Carreño, JT Cunningham… - Journal of …, 2009 - Soc Neuroscience
The nucleus of the solitary tract (NTS) receives inputs from both arterial chemoreceptors and
central noradrenergic neural structures activated during hypoxia. We investigated …