Background Immune responses to influenza vaccines decline with age, reducing clinical
effectiveness. We compared the effect of the more immunogenic high-dose trivalent …

Background A high-dose trivalent inactivated influenza vaccine was licensed in 2009 by the
US Food and Drug Administration (FDA) on the basis of serological criteria. We sought to …

OBJECTIVES: To evaluate the effect of staff influenza vaccination on all‐cause mortality in
nursing home residents. DESIGN: Pair‐matched cluster‐randomized trial. SETTING: Forty …

Background. Although annual influenza immunization is recommended for adults aged≥ 65
years due to the substantial burden of illness, the evidence base for this recommendation is …

Background Influenza vaccination of elderly individuals is recommended worldwide. Our
aim was to review the evidence of efficacy and effectiveness of influenza vaccines in …

Outbreaks of influenza in nursing homes still occur, even when a large portion of residents
have been inoculated with inactivated vaccine. Data were collected in 1991–1992 from 83 …

Background Reliable estimates of the effectiveness of influenza vaccine among persons 65
years of age and older are important for informed vaccination policies and programs. Short …

Background. Current evidence supporting the effectiveness of influenza vaccine in
preventing hospitalizations in older adults is insufficient. Methods. During 3 influenza …

Background Several aggregate data meta-analyses have provided estimates of the
effectiveness of influenza vaccination in community-dwelling elderly people. However, these …

Background The application of test-negative design case-control studies to assess the
effectiveness of influenza vaccine has increased substantially in the past few years. The …