Klotho is a putative aging suppressor gene encoding a single-pass transmembrane co-
receptor that makes the fibroblast growth factor (FGF) receptor specific for FGF-23. In …

Background The process of vascular calcification has been associated with the canonical
Wnt/β-catenin signalling pathway in cell cultures and animal studies. The relationship …

Renal tubular atrophy and interstitial fibrosis are common hallmarks of etiologically different
progressive chronic kidney diseases (CKD) that eventually result in organ failure. Even …

Klotho is a potent regulator of 1, 25-hydroxyvitamin D3 [1, 25 (OH) 2D3] formation and
calcium-phosphate metabolism. Klotho-hypomorphic mice (kl/kl mice) suffer from severe …

The high cardiovascular mortality associated with chronic kidney disease (CKD) is caused in
part by the CKD-mineral bone disorder (CKD-MBD) syndrome. The CKD-MBD consists of …

Aging is an independent risk factor for CKD, but the molecular mechanisms that link aging
and CKD are not well understood. The antiaging protein Klotho may be an endogenous …

AKI is increasingly recognized as a major risk factor for progression to CKD. However, the
factors governing AKI to CKD progression are poorly understood. In this study, we …

Autopsy studies have demonstrated the near universal presence of fatty streaks and
fibroatheromas in the general population from which patients with chronic kidney disease …

Podocyte dysfunction, one of the major causes of proteinuria, leads to glomerulosclerosis
and end stage renal disease, but its underlying mechanism remains poorly understood …

LDL receptor (LDLR)–null mice fed high-fat/cholesterol diets, a model of the metabolic
syndrome, have vascular calcification (VC) worsened by chronic kidney disease (CKD) and …