Distribution of the intermedilysin gene among the anginosus group streptococci and correlation between intermedilysin production and deep-seated infection with …

H Nagamune, RA Whiley, T Goto, Y Inai… - Journal of clinical …, 2000 - Am Soc Microbiol
The distribution of intermedilysin, a human-specific cytolysin, among the anginosus group
streptococci and the correlation of toxin production and infection by Streptococcus …

Intermedilysin, a novel cytotoxin specific for human cells secreted by Streptococcus intermedius UNS46 isolated from a human liver abscess

H Nagamune, C Ohnishi, A Katsuura… - Infection and …, 1996 - Am Soc Microbiol
A novel cytotoxin (intermedilysin) specific for human cells was identified as a cytolytic factor
of Streptococcus intermedius UNS46 isolated from a human liver abscess. Intermedilysin …

Effect on Polymorphonuclear Cell Function of a Human-Specific Cytotoxin, Intermedilysin, Expressed byStreptococcus intermedius

MG Macey, RA Whiley, L Miller… - Infection and …, 2001 - Am Soc Microbiol
Streptococcus intermedius is a member of the normal flora of the mouth but is also an
opportunistic pathogen associated with purulent infections at oral and nonoral sites …

Intermedilysin Is Essential for the Invasion of Hepatoma HepG2 Cells by Streptococcus intermedius

A Sukeno, H Nagamune, RA Whiley… - Microbiology and …, 2005 - Wiley Online Library
Streptococcus intermedius causes endogenous infections leading to abscesses. This
species produces intermedilysin (ILY), a human‐specific cytolysin. Because of the significant …

Role of Catabolite Control Protein A in the Regulation of Intermedilysin Production by Streptococcus intermedius

T Tomoyasu, A Tabata, R Hiroshima, H Imaki… - Infection and …, 2010 - Am Soc Microbiol
Streptococcus intermedius is an opportunistic pathogen of humans that causes purulent
infections, including brain and liver abscesses. This pathogen secretes a human-specific …

[HTML][HTML] Identification of the high affinity binding site in the Streptococcus intermedius toxin intermedilysin for its membrane receptor, the human complement regulator …

TR Hughes, KS Ross, GJM Cowan, B Sivasankar… - Molecular …, 2009 - Elsevier
The unique species specificity of the bacterial cytolysin intermedilysin is explained by its
requirement for the human complement regulator CD59 as the primary receptor. Binding …

Expression and Functional Properties of theStreptococcus intermedius Surface Protein Antigen I/II

FC Petersen, S Pasco, J Ogier, JP Klein… - Infection and …, 2001 - Am Soc Microbiol
Streptococcus intermedius is associated with deep-seated purulent infections. In this study,
we investigated expression and functional activities of antigen I/II in S. intermedius. The S …

The human‐specific action of intermedilysin, a homolog of streptolysin O, is dictated by domain 4 of the protein

H Nagamune, K Ohkura, A Sukeno… - Microbiology and …, 2004 - Wiley Online Library
Intermedilysin is a pore‐forming cytolysin belonging to the streptolysin O gene family known
as the 'Cholesterol‐binding/dependent cytolysins' and is unique within the family in that it is …

Identification of the anginosus group within the genus Streptococcus using polymerase chain reaction

A Takao, H Nagamune, N Maeda - FEMS microbiology letters, 2004 - academic.oup.com
The aim of this study was to establish an identification method for the anginosus group
within the genus Streptococcus by polymerase chain reaction (PCR). Using a primer pair …

Rapid identification of Streptococcus intermedius by PCR with the ily gene as a species marker gene

T Goto, H Nagamune, A Miyazaki… - Journal of medical …, 2002 - microbiologyresearch.org
Streptococcus intermedius belongs to the anginosus group of streptococci (AGS) and is
associated with endogenous infections leading to abscesses in the oral cavity and at deep …