Clinical trials have suggested that retinoid chemoprevention prevents the development of
second primary tumors following head and neck or non-small-cell lung cancer. The findings …

Even after smoking cessation, genetic damage in the airways epithelium may lead to focal
progression of lung carcinogenesis. Some centres now report as many new lung cancer …

Chemoprevention is a clinical strategy to block or reverse carcinogenesis before the
development of invasive cancer. Studies of chemoprevention in the lungs and upper …

Enthusiasm for the use of retinoic acids as chemopreventive agents in lung cancer has
waned in the last several years after patients in two large trials showed an unexpectedly …

Sarah J. Freemantle, Konstantin H. Dragnev, Ethan Dmitrovsky coming the systemic toxicity
associated with oral retinoid administration (13). Other approaches include the use of …

No chemoprevention strategies have been proven effective for lung cancer. We evaluated
the effect of 13-cis retinoic acid (13-cis RA), with or without α tocopherol, as a lung cancer …

Lung cancer is the leading cause of cancer death in the United States. The persisting grim
lung cancer incidence and mortality figures argue powerfully for new approaches such as …

EPITHELIAL CANCERS of the lung and head and neck account for 30% of all United States
cancer deaths and are a major cause of death throughout the world. Despite intensive …

Epithelial cancers in the lung and head and neck are a devastating group of diseases which
account for approximately 35% of cancer deaths in the United States. Chemoprevention is a …

Several in vitro and in vivo studies have examined the positive and negative effects of
retinoids (vitamin A analogs) in premalignant and malignant lesions. Retinoids have been …