Mitochondria are major energy-producing organelles that have central roles in cellular
metabolism. They also act as important signalling hubs, and their dynamic regulation in …

Control of excessive mitochondrial oxidative stress could provide new targets for both
preventive and therapeutic interventions in the treatment of chronic inflammation or any …

Rheumatoid arthritis is an autoimmune disease characterized by chronic symmetric synovial
inflammation and erosive bone destruction. Mitochondria are the main site of cellular energy …

The mitochondrion is an intracellular organelle thought to originate from endosymbiosis
between an ancestral eukaryotic cell and an α-proteobacterium. Mitochondria are the …

Rheumatoid arthritis, a chronic autoimmune disease with complex etiology, is characterized
by excessive proliferation of synovial cells, massive production of inflammatory cells and …

Rheumatic and musculoskeletal diseases are a heterogeneous group of disorders affecting
joint tissues and in some cases even organs, some of them being among the most common …

Nucleic acid autoantibodies, increase type I interferon (IFN-α) levels, and immune cell
hyperactivation are hallmarks of systemic lupus erythematosus (SLE). Notably, immune cell …

Synoviocytes are located in the synovium lining layer, which is composed of macrophage-
like synoviocytes (MLS) and fibroblast-like synoviocytes (FLS) with different characteristics …

Purpose of Review Mitochondria are recognized to be one of the most important organelles
in chondrocytes for their role in triphosphate (ATP) generation through aerobic …

Abstract Purpose of Review Systemic lupus erythematosus (SLE) is an autoimmune disease
characterized by autoantibody production and inflammation in multiple organs. In this article …