Cytotoxic T and natural killer (NK) cells of the immune system are responsible for controlling
potentially fatal viral infections. Their weaponry includes lethal granules which contain …

Cytolytic T lymphocytes (CTL), natural killer cells, and lymphokine-activated killer (LAK) cells
are cytolytic cells known to release the cytolytic protein perforin and a family of proteases …

Cytolytic T lymphocytes (CTL) and large granular lymphocytes contain dense cytoplasmic
granules which, when isolated, are lytic for a variety of target cells. Granule proteins are …

Calreticulin is a component of cytotoxic T-lymphocyte and NK lymphocyte granules. We
report here that granule-associated calreticulin terminates with the KDEL endoplasmic …

One mechanism of killing by cytotoxic lymphocytes involves the exocytosis of specialized
granules. The released granules contain perforin, which assembles into pores in the …

Perforin and granzymes are considered to be instrumental in cell-mediated cytolysis by
cytotoxic Tcells and natural killer cells. Here, Gillian Griffith and Christoph Mueller describe …

The components within cytotoxic lymphocyte granules are responsible for a significant
fraction of T and NK cell-mediated death. Perforin is stored in these granules together with …

New functions are implicated for calreticulin, based on its release from cytotoxic NK and T
cells. Calreticulin is the only one of six “KDEL”(Lys-Asp-Glu-Leu carboxy terminal) …

The Ca2+-dependent cytolytic activity of isolated T-lymphocyte granules was purified to
apparent homogeneity by high-salt extraction, gel filtration, and ion-exchange …

Abstract Perforin, a Ca2+-dependent pore forming protein found in the granules of natural
killer (NK) cells and cytotoxic T lymphocytes (CTLs), was once proposed to be “the sole …