The cytolytic potential of T effector cells appears to be intimately related to the presence of
proteins stored in specialized cytoplasmic granules. A striking biological property of isolated …

A key cytolytic mediator used by killer lymphocytes, perforin (also known as pore-forming
protein or cytolysin), has been shown to be capable of undergoing polymerization to form …

Earthworm (Eisenia fetida) coelomic fluid contains several leukocytes (coelomocytes):
basophils, acidophils and neutrophils as well as chloragocytes. Small coelomocytes and …

Natural killer cells and cytotoxic T lymphocytes accomplish the critically important function of
killing virus-infected and neoplastic cells. They do this by releasing the pore-forming protein …

Perforin Is one of the important cytolytlc factors in cytotoxlc T lymphocytes (CTL) and natural
killer (NK) cells. In this paper, we report rat mAbs against mouse perforln established by …

Expression of the pore‐forming protein perforin is normally restricted to the cytolytic granules
of cytotoxic T lymphocytes and natural killer cells. Perforin, which causes cell death by …

Lymphocytes kill tumor cells and other target cells by a contact-dependent mechanism. Killer
lymphocytes acquire cytoplasmic granules upon lymphokine stimulation and these granules …

Granule-mediated cytolysis is undoubtedly the most important effector function of CD8+ T
cells and natural killer (NK) cells. After a killer cell recognizes its target, the cytotoxic …

Cytotoxic T lymphocytes (CTL) and natural killer (NK) cells form a part of the immune system
and play crucial roles in defence against virally infected and neoplastic cells. They are …

During granule-mediated killing by cytotoxic T lymphocytes or natural killer cells, the serine
protease granzyme B enters the target cell by endocytosis and induces apoptosis. Previous …