Genetic alterations in the PIK3CA gene of the phosphoinositide 3-kinase (PI3K)/AKT
pathway have been found in many human tumors, but they have not been explored in …

The tumorigenesis of pituitary adenomas is poorly understood. Mutations of the PIK3CA
proto-oncogene, which encodes the p110-α catalytic subunit of PI3K, have been reported in …

Context: As in many other human cancers, overactivation of the phosphotidylinositol 3-
kinase (PI3K)/Akt signaling pathway occurs frequently in thyroid cancer, but the mechanism …

Context: Genetic aberration in phosphatidylinositol 3-kinase (PI3K)/AKT pathway has been
detected in numerous and diverse human cancers. PIK3CA, which encodes for the catalytic …

PIK3CA belongs to the phosphatidylinositol 3‐kinases (PI3Ks) family, which play an
important role in proliferation, adherence, transformation and cell survival through the …

Abstract The phosphatidylinositol 3-kinases (PI3K) are a family of enzymes that relay
important cellular growth control signals. Recently, a large-scale mutational analysis of eight …

Purpose: Recent studies have reported high frequencies of somatic mutations in the
phosphoinositide-3-kinase catalytic α (PIK3CA) gene in several human solid tumors …

Phosphatidylinositol 3-kinases (PI3Ks) are important regulators of signaling pathways. To
determine whether PI3Ks are genetically altered in human cancers, we recently analyzed …

The involvement of the PIK3CA gene product p110α, the catalytic subunit of
phosphatidylinositol 3-kinase (PI3K), in human cancer has been suggested for over 15 …

Purpose: Activation of the phosphatidylinositol 3-kinase (PI3K)-AKT pathway, resulting in
increased cell proliferation, survival, and motility, is believed to play an oncogenic role in …