We aimed to investigate oxidative stress biomarkers in a cross-sectional pilot study of 50
participants with sporadic ALS (SALS) compared to 46 control subjects. We measured …

Oxidative stress has been reported to be involved in the onset and development of
amyotrophic lateral sclerosis (ALS). Data from clinical studies have highlighted increased …

Background: Pathophysiological mechanisms that contribute to neurodegeneration in
Amyotrophic Lateral Sclerosis (ALS) include oxidative stress and inflammation. We …

Sporadic amyotrophic lateral sclerosis (ALS) is one of the most devastating neurological
diseases; most patients die within 3 to 4 years after symptom onset. Oxidative stress is a …

Background: Markers of oxidative stress and immune activation are significantly elevated in
postmortem ALS CNS tissue, although the relevance to pathogenesis is unclear. Objective …

Our objective was to identify metabolic pathways affected by ALS using non-targeted
metabolomics in plasma, comparing samples from healthy volunteers to those from ALS …

Amyotrophic lateral sclerosis (ALS), also known as motor neuron disease (MND) and Lou
Gehrig's disease, is characterized by a loss of the lower motor neurons in the spinal cord …

Some cases of autosomal dominant familial amyotrophic lateral sclerosis (FALS) are
associated with mutations in the gene encoding Cu/Zn superoxide dismutase (SOD1) …

Background Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease affecting
upper and lower motor neurons in the CNS and leading to paralysis and death. There are …

Oxidative stress markers have been found in nervous and peripheral tissues of familial and
sporadic amyotrophic lateral sclerosis patients. Here, we evaluated the activity of some …