Mechanisms of muscle insulin resistance and the cross‐talk with liver and adipose tissue

SC da Silva Rosa, N Nayak, AM Caymo… - Physiological …, 2020 - Wiley Online Library
Insulin resistance is a metabolic disorder affecting multiple tissues and is a precursor event
to type 2 diabetes (T2D). As T2D affects over 425 million people globally, there is an …

Muscle and adipose tissue insulin resistance: malady without mechanism?

DJ Fazakerley, JR Krycer, AL Kearney… - Journal of Lipid …, 2019 - ASBMB
Insulin resistance is a major risk factor for numerous diseases, including type 2 diabetes and
cardiovascular disease. These disorders have dramatically increased in incidence with …

[HTML][HTML] Insulin resistance: from mechanisms to therapeutic strategies

SH Lee, SY Park, CS Choi - Diabetes & metabolism journal, 2022 - synapse.koreamed.org
Insulin resistance is the pivotal pathogenic component of many metabolic diseases,
including type 2 diabetes mellitus, and is defined as a state of reduced responsiveness of …

[HTML][HTML] Mechanisms of insulin action and insulin resistance

MC Petersen, GI Shulman - Physiological reviews, 2018 - journals.physiology.org
The 1921 discovery of insulin was a Big Bang from which a vast and expanding universe of
research into insulin action and resistance has issued. In the intervening century, some …

Insulin resistance: Review of the underlying molecular mechanisms

H Yaribeygi, FR Farrokhi, AE Butler… - Journal of cellular …, 2019 - Wiley Online Library
Most human cells utilize glucose as the primary substrate, cellular uptake requiring insulin.
Insulin signaling is therefore critical for these tissues. However, decrease in insulin …

Mechanisms of insulin resistance in humans and possible links with inflammation

DB Savage, KF Petersen, GI Shulman - Hypertension, 2005 - Am Heart Assoc
Insulin resistance is a major player in the pathogenesis of the metabolic syndrome and type
2 diabetes, and yet, the mechanisms responsible for it remain poorly understood. Magnetic …

Pathogenesis of insulin resistance in skeletal muscle

MA Abdul-Ghani, RA DeFronzo - BioMed Research …, 2010 - Wiley Online Library
Insulin resistance in skeletal muscle is manifested by decreased insulin‐stimulated glucose
uptake and results from impaired insulin signaling and multiple post‐receptor intracellular …

Insulin resistance in type 1 diabetes mellitus

K Kaul, M Apostolopoulou, M Roden - Metabolism, 2015 - Elsevier
For long the presence of insulin resistance in type 1 diabetes has been questioned. Detailed
metabolic analyses revealed 12%–61% and up to 20% lower whole-body (skeletal muscle) …

Mechanisms for insulin resistance: common threads and missing links

VT Samuel, GI Shulman - Cell, 2012 - cell.com
Insulin resistance is a complex metabolic disorder that defies explanation by a single
etiological pathway. Accumulation of ectopic lipid metabolites, activation of the unfolded …

Skeletal muscle insulin resistance: role of inflammatory cytokines and reactive oxygen species

Y Wei, K Chen, AT Whaley-Connell… - American Journal …, 2008 - journals.physiology.org
The cardiometabolic syndrome (CMS), with its increased risk for cardiovascular disease
(CVD), nonalcoholic fatty liver disease (NAFLD), and chronic kidney disease (CKD), has …