Mechanisms of muscle insulin resistance and the cross‐talk with liver and adipose tissue
SC da Silva Rosa, N Nayak, AM Caymo… - Physiological …, 2020 - Wiley Online Library
Insulin resistance is a metabolic disorder affecting multiple tissues and is a precursor event
to type 2 diabetes (T2D). As T2D affects over 425 million people globally, there is an …
to type 2 diabetes (T2D). As T2D affects over 425 million people globally, there is an …
Muscle and adipose tissue insulin resistance: malady without mechanism?
DJ Fazakerley, JR Krycer, AL Kearney… - Journal of Lipid …, 2019 - ASBMB
Insulin resistance is a major risk factor for numerous diseases, including type 2 diabetes and
cardiovascular disease. These disorders have dramatically increased in incidence with …
cardiovascular disease. These disorders have dramatically increased in incidence with …
[HTML][HTML] Insulin resistance: from mechanisms to therapeutic strategies
SH Lee, SY Park, CS Choi - Diabetes & metabolism journal, 2022 - synapse.koreamed.org
Insulin resistance is the pivotal pathogenic component of many metabolic diseases,
including type 2 diabetes mellitus, and is defined as a state of reduced responsiveness of …
including type 2 diabetes mellitus, and is defined as a state of reduced responsiveness of …
[HTML][HTML] Mechanisms of insulin action and insulin resistance
MC Petersen, GI Shulman - Physiological reviews, 2018 - journals.physiology.org
The 1921 discovery of insulin was a Big Bang from which a vast and expanding universe of
research into insulin action and resistance has issued. In the intervening century, some …
research into insulin action and resistance has issued. In the intervening century, some …
Insulin resistance: Review of the underlying molecular mechanisms
Most human cells utilize glucose as the primary substrate, cellular uptake requiring insulin.
Insulin signaling is therefore critical for these tissues. However, decrease in insulin …
Insulin signaling is therefore critical for these tissues. However, decrease in insulin …
Mechanisms of insulin resistance in humans and possible links with inflammation
DB Savage, KF Petersen, GI Shulman - Hypertension, 2005 - Am Heart Assoc
Insulin resistance is a major player in the pathogenesis of the metabolic syndrome and type
2 diabetes, and yet, the mechanisms responsible for it remain poorly understood. Magnetic …
2 diabetes, and yet, the mechanisms responsible for it remain poorly understood. Magnetic …
Pathogenesis of insulin resistance in skeletal muscle
MA Abdul-Ghani, RA DeFronzo - BioMed Research …, 2010 - Wiley Online Library
Insulin resistance in skeletal muscle is manifested by decreased insulin‐stimulated glucose
uptake and results from impaired insulin signaling and multiple post‐receptor intracellular …
uptake and results from impaired insulin signaling and multiple post‐receptor intracellular …
Insulin resistance in type 1 diabetes mellitus
K Kaul, M Apostolopoulou, M Roden - Metabolism, 2015 - Elsevier
For long the presence of insulin resistance in type 1 diabetes has been questioned. Detailed
metabolic analyses revealed 12%–61% and up to 20% lower whole-body (skeletal muscle) …
metabolic analyses revealed 12%–61% and up to 20% lower whole-body (skeletal muscle) …
Mechanisms for insulin resistance: common threads and missing links
VT Samuel, GI Shulman - Cell, 2012 - cell.com
Insulin resistance is a complex metabolic disorder that defies explanation by a single
etiological pathway. Accumulation of ectopic lipid metabolites, activation of the unfolded …
etiological pathway. Accumulation of ectopic lipid metabolites, activation of the unfolded …
Skeletal muscle insulin resistance: role of inflammatory cytokines and reactive oxygen species
Y Wei, K Chen, AT Whaley-Connell… - American Journal …, 2008 - journals.physiology.org
The cardiometabolic syndrome (CMS), with its increased risk for cardiovascular disease
(CVD), nonalcoholic fatty liver disease (NAFLD), and chronic kidney disease (CKD), has …
(CVD), nonalcoholic fatty liver disease (NAFLD), and chronic kidney disease (CKD), has …