Computational kinetic model of VEGF trapping by soluble VEGF receptor-1: effects of transendothelial and lymphatic macromolecular transport

FTH Wu, MO Stefanini, F Mac Gabhann… - Physiological …, 2009 - journals.physiology.org
Vascular endothelial growth factor (VEGF) signal transduction through the cell surface
receptors VEGFR1 and VEGFR2 regulates angiogenesis—the growth of new capillaries …

[HTML][HTML] A compartment model of VEGF distribution in humans in the presence of soluble VEGF receptor-1 acting as a ligand trap

FTH Wu, MO Stefanini, F Mac Gabhann, AS Popel - PloS one, 2009 - journals.plos.org
Vascular endothelial growth factor (VEGF), through its activation of cell surface receptor
tyrosine kinases including VEGFR1 and VEGFR2, is a vital regulator of stimulatory and …

[HTML][HTML] The presence of VEGF receptors on the luminal surface of endothelial cells affects VEGF distribution and VEGF signaling

MO Stefanini, FTH Wu, F Mac Gabhann… - PLoS computational …, 2009 - journals.plos.org
Vascular endothelial growth factor (VEGF) is a potent cytokine that binds to specific
receptors on the endothelial cells lining blood vessels. The signaling cascade triggered …

[HTML][HTML] Formation of VEGF isoform-specific spatial distributions governing angiogenesis: computational analysis

P Vempati, AS Popel… - BMC systems …, 2011 - bmcsystbiol.biomedcentral.com
The spatial distribution of vascular endothelial growth factor A (VEGF) is an important
mediator of vascular patterning. Previous experimental studies in the mouse hindbrain and …

[HTML][HTML] A compartment model of VEGF distribution in blood, healthy and diseased tissues

MO Stefanini, FTH Wu, F Mac Gabhann, AS Popel - BMC systems biology, 2008 - Springer
Background Angiogenesis is a process by which new capillaries are formed from pre-
existing blood vessels in physiological (eg, exercise, wound healing) or pathological (eg …

[HTML][HTML] Site-specific phosphorylation of VEGFR2 is mediated by receptor trafficking: insights from a computational model

LW Clegg, F Mac Gabhann - PLoS computational biology, 2015 - journals.plos.org
Matrix-binding isoforms and non-matrix-binding isoforms of vascular endothelial growth
factor (VEGF) are both capable of stimulating vascular remodeling, but the resulting blood …

[HTML][HTML] Compartment model predicts VEGF secretion and investigates the effects of VEGF trap in tumor-bearing mice

SD Finley, M Dhar, AS Popel - Frontiers in oncology, 2013 - frontiersin.org
Angiogenesis, the formation of new blood vessels from existing vasculature, is important in
tumor growth and metastasis. A key regulator of angiogenesis is vascular endothelial growth …

A systems biology perspective on sVEGFR1: its biological function, pathogenic role and therapeutic use

FTH Wu, MO Stefanini, FM Gabhann… - Journal of cellular …, 2010 - Wiley Online Library
Introduction‐Angiogenesis in physiology and pathology‐Angiogenesis in current medicine‐
VEGF ligand and receptor system: where does sVEGFR1 fit?‐Ligands: the human VEGF …

[HTML][HTML] A two-compartment model of VEGF distribution in the mouse

P Yen, SD Finley, MO Engel-Stefanini, AS Popel - PloS one, 2011 - journals.plos.org
Vascular endothelial growth factor (VEGF) is a key regulator of angiogenesis–the growth of
new microvessels from existing microvasculature. Angiogenesis is a complex process …

Modeling of growth factor-receptor systems: from molecular-level protein interaction networks to whole-body compartment models

FTH Wu, MO Stefanini, F Mac Gabhann… - Methods in enzymology, 2009 - Elsevier
Most physiological processes are subjected to molecular regulation by growth factors, which
are secreted proteins that activate chemical signal transduction pathways through binding of …