Vegfr endocytosis: implications for angiogenesis
Q Saikia, H Reeve, A Alzahrani, WR Critchley… - Progress in Molecular …, 2023 - Elsevier
The binding of vascular endothelial growth factor (VEGF) superfamily to VEGF receptor
tyrosine kinases (VEGFRs) and co-receptors regulates vasculogenesis, angiogenesis and …
tyrosine kinases (VEGFRs) and co-receptors regulates vasculogenesis, angiogenesis and …
A hybrid model of the role of VEGF binding in endothelial cell migration and capillary formation
HV Jain, TL Jackson - Frontiers in oncology, 2013 - frontiersin.org
Vascular endothelial growth factor (VEGF) is the most studied family of soluble, secreted
mediators of endothelial cell migration, survival, and proliferation. VEGF exerts its function …
mediators of endothelial cell migration, survival, and proliferation. VEGF exerts its function …
Quantification and cell-to-cell variation of vascular endothelial growth factor receptors
PI Imoukhuede, AS Popel - Experimental cell research, 2011 - Elsevier
The vascular endothelial growth factor receptors (VEGFR) play a significant role in
angiogenesis, the formation of new blood vessels from existing vasculature. Systems …
angiogenesis, the formation of new blood vessels from existing vasculature. Systems …
A computational analysis of in vivo VEGFR activation by multiple co-expressed ligands
LE Clegg, F Mac Gabhann - PLoS computational biology, 2017 - journals.plos.org
The splice isoforms of vascular endothelial growth A (VEGF) each have different affinities for
the extracellular matrix (ECM) and the coreceptor NRP1, which leads to distinct vascular …
the extracellular matrix (ECM) and the coreceptor NRP1, which leads to distinct vascular …
An inside view: VEGF receptor trafficking and signaling
M Simons - Physiology, 2012 - journals.physiology.org
Vascular endothelial growth factors (VEGF) and their receptors play a central role in the
development of cardiovascular system and in vasculature-related processes in the adult …
development of cardiovascular system and in vasculature-related processes in the adult …
Systems biology of vascular endothelial growth factors
FM Gabhann, AS Popel - Microcirculation, 2008 - Taylor & Francis
Several cytokine families have roles in the development, maintenance, and remodeling of
the microcirculation. Of these, the vascular endothelial growth factor (VEGF) family is one of …
the microcirculation. Of these, the vascular endothelial growth factor (VEGF) family is one of …
The VEGFR2 receptor tyrosine kinase undergoes constitutive endosome-to-plasma membrane recycling
HM Jopling, GJ Howell, N Gamper… - … and biophysical research …, 2011 - Elsevier
The VEGFR2 receptor tyrosine kinase regulates vascular physiology and animal
development. The mechanism underlying VEGFR2 membrane trafficking is not well …
development. The mechanism underlying VEGFR2 membrane trafficking is not well …
Differential binding of VEGF isoforms to VEGF receptor 2 in the presence of neuropilin-1: a computational model
F Mac Gabhann, AS Popel - American Journal of …, 2005 - journals.physiology.org
A comprehensive, biophysically accurate, computational model of vascular endothelial
growth factor (VEGF) family member interactions with endothelial cell surface receptors was …
growth factor (VEGF) family member interactions with endothelial cell surface receptors was …
Constitutive endocytosis of VEGFR2 protects the receptor against shedding
D Basagiannis, S Christoforidis - Journal of Biological Chemistry, 2016 - ASBMB
VEGFR2 plays a fundamental role in blood vessel formation and in life threatening diseases,
such as cancer angiogenesis and cardiovascular disorders. Although inactive growth factor …
such as cancer angiogenesis and cardiovascular disorders. Although inactive growth factor …
VEGFR3 modulates vascular permeability by controlling VEGF/VEGFR2 signaling
K Heinolainen, S Karaman, G D'Amico… - Circulation …, 2017 - Am Heart Assoc
Rationale: Vascular endothelial growth factor (VEGF) is the main driver of angiogenesis and
vascular permeability via VEGF receptor 2 (VEGFR2), whereas lymphangiogenesis signals …
vascular permeability via VEGF receptor 2 (VEGFR2), whereas lymphangiogenesis signals …