The genetics and genomics of Trypanosoma cruzi

MP Vazquez - 2007 - ri.conicet.gov.ar
Trypanosoma cruzi is a kinetoplastid parasite that causes Chagas disease. Trypanosomes
are unusual organisms in many aspects of its genetics and molecular and cellular biology …

In Vivo Analysis of Trypanosoma cruzi Persistence Foci at Single-Cell Resolution

AI Ward, MD Lewis, AA Khan, CJ McCann… - Mbio, 2020 - Am Soc Microbiol
Infections with Trypanosoma cruzi are usually lifelong despite generating a strong adaptive
immune response. Identifying the sites of parasite persistence is therefore crucial to …

Incomplete recruitment of protective T cells is associated with trypanosoma cruzi persistence in the mouse colon

AI Ward, MD Lewis, MC Taylor, JM Kelly - Infection and Immunity, 2022 - Am Soc Microbiol
Trypanosoma cruzi is the etiological agent of Chagas disease. Following T cell-mediated
suppression of acute-phase infection, this intracellular eukaryotic pathogen persists long …

Comparative transcriptome profiling of virulent and non-virulent Trypanosoma cruzi underlines the role of surface proteins during infection

AT Belew, C Junqueira, GF Rodrigues-Luiz… - PLoS …, 2017 - journals.plos.org
Trypanosoma cruzi, the protozoan that causes Chagas disease, has a complex life cycle
involving several morphologically and biochemically distinct stages that establish intricate …

[HTML][HTML] Mammalian cell invasion and intracellular trafficking by Trypanosoma cruzi infective forms

RA Mortara, WK Andreoli, NN Taniwaki… - Anais da Academia …, 2005 - SciELO Brasil
Trypanosoma cruzi, the etiological agent of Chagas' disease, occurs as different strains or
isolates that may be grouped in two major phylogenetic lineages: T. cruzi I, associated with …

Review on Trypanosoma cruzi: Host Cell Interaction

W De Souza, TMU De Carvalho… - International journal of …, 2010 - Wiley Online Library
Trypanosoma cruzi, the causative agent of Chagas′ disease, which affects a large number
of individuals in Central and South America, is transmitted to vertebrate hosts by blood …

An Updated View of the Trypanosoma cruzi Life Cycle: Intervention Points for an Effective Treatment

J Martín-Escolano, C Marín, MJ Rosales… - ACS Infectious …, 2022 - ACS Publications
Chagas disease (CD) is a parasitic, systemic, chronic, and often fatal illness caused by
infection with the protozoan Trypanosoma cruzi. The World Health Organization classifies …

[HTML][HTML] Close encounters between Trypanosoma cruzi and the host mammalian cell: Lessons from genome-wide expression studies

AER Oliveira, V Grazielle-Silva, LRP Ferreira… - Genomics, 2020 - Elsevier
Trypanosoma cruzi is the etiologic agent of Chagas disease, a life-threatening disease that
affects different tissues. Within its mammalian host, T. cruzi develops molecular strategies for …

[HTML][HTML] Purification of extracellular and intracellular amastigotes of Trypanosoma cruzi from mammalian host-infected cells

A Marques, E Nakayasu, I Almeida - 2011 - researchsquare.com
The protozoan parasite Trypanosoma cruzi is the etiologic agent of Chagas disease, which
affects millions of people in Latin America. T. cruzi has a complex life cycle characterized by …

Transcriptome Remodeling in Trypanosoma cruzi and Human Cells during Intracellular Infection

Y Li, S Shah-Simpson, K Okrah, AT Belew… - PLoS …, 2016 - journals.plos.org
Intracellular colonization and persistent infection by the kinetoplastid protozoan parasite,
Trypanosoma cruzi, underlie the pathogenesis of human Chagas disease. To obtain global …