The intracellular cycle of Trypanosoma cruzi in mammalian host cells involves the
differentiation of dividing amastigote forms into flagellated trypomastigote forms. The …

Trypanosoma cruzi, the causative agent of Chagas heart disease, infects heart and other
cells leading to cardiac arrest frequently followed by death (1). The disease affects millions …

On 15 July 2020 was the 15th anniversary of the Science Magazine issue that reported three
trypanosomatid genomes, namely Leishmania major, Trypanosoma brucei, and …

Background The requirements for growth and survival of the intracellular pathogen
Trypanosoma cruzi within mammalian host cells are poorly understood. Transcriptional …

Benznidazole is the front-line drug used to treat infections with Trypanosoma cruzi, the
causative agent of Chagas disease. However, for reasons that are unknown, treatment …

Naturally occurring DNA variants of the single-cell-derived Y-02 stock of Trypanosoma cruzi
were discovered during a routine assay of the stock. Three DNA variant types were isolated …

Among the different infective stages that Trypanosoma cruzi employs to invade cells,
extracellular amastigotes (EAs) have recently gained attention by our group. This is true …

Chagas disease is a debilitating human illness caused by infection with the protozoan
Trypanosoma cruzi. A capacity to invade and replicate within many different cell types is a …

Trypanosomatids are ancient parasitic eukaryotes that still maintain prokaryotic
characteristics. Trypanosoma cruzi, a primarily wild mammal parasite, infected humans …

Chagas disease is mainly transmitted by vertical transmission (VT) in nonendemic areas
and in endemic areas where vector control programs have been successful. For the present …