Mechanisms of Infectivity and Evasion Derived from Microvesicles Cargo Produced by Trypanosoma cruzi

BC Borges, IA Uehara, LOS Dias, PC Brígido… - Frontiers in Cellular …, 2016 - frontiersin.org
Cell invasion by the intracellular protozoans requires interaction of proteins from both the
host and the parasite. Many parasites establish chronic infections, showing they have the …

Trypanosoma cruzi induces cellular proliferation in the trophoblastic cell line BeWo

D Droguett, I Carrillo, C Castillo, F Gómez… - Experimental …, 2017 - Elsevier
Congenital transmission of Trypanosoma cruzi (T. cruzi) is partially responsible for the
progressive globalization of Chagas disease. During congenital transmission the parasite …

Microarray profiling of gene expression during trypomastigote to amastigote transition in Trypanosoma cruzi

TA Minning, J Bua, GA Garcia, RA McGraw… - Molecular and …, 2003 - Elsevier
Trypanosoma cruzi, the causative agent of Chagas disease, remains a significant public
health concern throughout South and Central America. Although much is known about …

Trypanosoma cruzi: Flow Cytometric Analysis of Developmental Stage Differences in DNA

T NOZAKI, JA DVORAK - The Journal of protozoology, 1991 - Wiley Online Library
Flow cytometry and DNA binding‐specific fluorescent reagents were used to compare the
total DNA, G‐C, and A‐T content of the epimastigote and trypomastigote stages of …

Immediate/early response to Trypanosoma cruzi infection involves minimal modulation of host cell transcription

SV De Avalos, IJ Blader, M Fisher, JC Boothroyd… - Journal of Biological …, 2002 - ASBMB
Host cell infection by the intracellular pathogen, Trypanosoma cruzi, involves activation of
signaling pathways, cytoskeletal reorganization, and targeted recruitment of host cell …

Impact of Laboratory-Adapted Intracellular Trypanosoma cruzi Strains on the Activity Profiles of Compounds with Anti-T. cruzi Activity

ML Sykes, EK Kennedy, VM Avery - Microorganisms, 2023 - mdpi.com
Chagas disease is caused by infection with the protozoan parasite, Trypanosoma cruzi. The
disease causes~ 12,000 deaths annually and is one of the world's 20 neglected tropical …

Transmigration of Trypanosoma cruzi trypomastigotes through 3D cultures resembling a physiological environment

ME Rodríguez, M Rizzi, LD Caeiro… - Cellular …, 2020 - Wiley Online Library
To disseminate and colonise tissues in the mammalian host, Trypanosoma cruzi
trypomastogotes should cross several biological barriers. How this process occurs or its …

Genomic assemblies of newly sequenced Trypanosoma cruzi strains reveal new genomic expansion and greater complexity

F Callejas-Hernández, A Rastrojo, C Poveda… - Scientific reports, 2018 - nature.com
Chagas disease is a complex illness caused by the protozoan Trypanosoma cruzi
displaying highly diverse clinical outcomes. In this sense, the genome sequence elucidation …

Strain-specific genome evolution in Trypanosoma cruzi, the agent of Chagas disease

W Wang, D Peng, RP Baptista, Y Li, JC Kissinger… - PLoS …, 2021 - journals.plos.org
The protozoan Trypanosoma cruzi almost invariably establishes life-long infections in
humans and other mammals, despite the development of potent host immune responses …

Trypanosoma cruzi: Gene Expression Surveyed by Proteomic Analysis Reveals Interaction between Different Genotypes in Mixed In Vitro Cultures

A Machin, J Telleria, JP Brizard, E Demettre, M Seveno… - Plos one, 2014 - journals.plos.org
We have analyzed the comportment in in vitro culture of 2 different genotypes of
Trypanosoma cruzi, the agent of Chagas disease, pertaining to 2 major genetic subdivisions …