Replication Protein A (RPA), the major single stranded DNA binding protein in eukaryotes, is
composed of three subunits and is a fundamental player in DNA metabolism, participating in …

Through its life cycle from the insect vector to mammalian hosts Trypanosoma cruzi has
developed clever strategies to reach the intracellular milieu where it grows sheltered from …

Trypanosoma cruzi is the causative agent of Chagas' disease. Novel chemotherapy with the
drug K11777 targets the major cysteine protease cruzain and disrupts amastigote …

Trypanosoma cruzi alternates between different morphological and functional types during
its life cycle. Since the discovery of this parasite at the beginning of the twentieth century …

Abstract Background Trypanosoma conorhini and Trypanosoma rangeli, like Trypanosoma
cruzi, are kinetoplastid protist parasites of mammals displaying divergent hosts, geographic …

Chagas' disease is still a worldwide threat, with estimated from 6 to 7 million infected people,
mainly in Latin America. Despite all efforts, especially from international consortia (DNDi …

Background DNA replication in trypanosomatids operates in a uniquely challenging
environment, since most of their genomes are constitutively transcribed. Trypanosoma cruzi …

Trypanosoma cruzi, a protozoan parasite that causes Chagas disease, exhibits unique
mechanisms for gene expression such as constitutive polycistronic transcription of protein …

BACKGROUND Trypanosoma cruzi circulates in sylvatic habitats, mainly through blood-
feeding triatomines, although other routes also contribute to its dispersion. Sexual …

Infection with the protozoan parasite Trypanosoma cruzi, the agent of Chagas disease, is
characterised by a variable clinical course–from symptomless cases to severe chronic …