Differential infectivity of two Trypanosoma cruzi strains in placental cells and tissue

L Medina, C Castillo, A Liempi, M Herbach, G Cabrera… - Acta tropica, 2018 - Elsevier
Congenital Chagas disease, caused by Trypanosoma cruzi (T. cruzi), has become
epidemiologically relevant. The probability of congenital transmission depends on the …

[HTML][HTML] Can sexual transmission support the enzootic cycle of Trypanosoma cruzi?

A Rios, M Ribeiro, A Sousa, F Pimentel… - Memórias do Instituto …, 2018 - SciELO Brasil
BACKGROUND Trypanosoma cruzi circulates in sylvatic habitats, mainly through blood-
feeding triatomines, although other routes also contribute to its dispersion. Sexual …

[HTML][HTML] In vivo imaging of mice infected with bioluminescent Trypanosoma cruzi unveils novel sites of infection

C Henriques, A Henriques-Pons, M Meuser-Batista… - Parasites & vectors, 2014 - Springer
Background The development of techniques that allow the imaging of animals infected with
parasites expressing luciferase opens up new possibilities for following the fate of parasites …

TcI, TcII and TcVI Trypanosoma cruzi samples from Chagas disease patients with distinct clinical forms and critical analysis of in vitro and in vivo behavior, response to …

MT de Oliveira, RT Branquinho, GD Alessio… - Acta Tropica, 2017 - Elsevier
The clonal evolution of Trypanosoma cruzi sustains scientifically the hypothesis of
association between parasite's genetic, biological behavior and possibly the clinical aspects …

[HTML][HTML] Repeat-Driven Generation of Antigenic Diversity in a Major Human Pathogen, Trypanosoma cruzi

C Talavera-López, LA Messenger, MD Lewis… - Frontiers in cellular …, 2021 - frontiersin.org
Trypanosoma cruzi, a zoonotic kinetoplastid protozoan parasite, is the causative agent of
American trypanosomiasis (Chagas disease). Having a very plastic, repetitive and complex …

The endless race between Trypanosoma cruzi and host immunity: lessons for and beyond Chagas disease

C Junqueira, B Caetano, DC Bartholomeu… - Expert reviews in …, 2010 - cambridge.org
Infection with the protozoan parasite Trypanosoma cruzi, the agent of Chagas disease, is
characterised by a variable clinical course–from symptomless cases to severe chronic …

[HTML][HTML] Flow cytometric analysis and microsatellite genotyping reveal extensive DNA content variation in Trypanosoma cruzi populations and expose contrasts …

MD Lewis, MS Llewellyn, MW Gaunt, M Yeo… - International journal for …, 2009 - Elsevier
Trypanosoma cruzi exhibits remarkable genetic heterogeneity. This is evident at the
nucleotide level but also structurally, in the form of karyotypic variation and DNA content …

[HTML][HTML] Chromosomal copy number variation reveals differential levels of genomic plasticity in distinct Trypanosoma cruzi strains

JL Reis-Cunha, GF Rodrigues-Luiz, HO Valdivia… - BMC genomics, 2015 - Springer
Background Trypanosoma cruzi, the etiologic agent of Chagas disease, is currently divided
into six discrete typing units (DTUs), named TcI–TcVI. CL Brener, the reference strain of the …

[HTML][HTML] Trypanosoma cruzi clonal diversity and the epidemiology of Chagas' disease

CA Buscaglia, JM Di Noia - Microbes and infection, 2003 - Elsevier
Chagas' disease is caused by the protozoan Trypanosoma cruzi and it has a variable
clinical outcome. The basis for this variability relies in part on the complexity of the parasite …

Microevolution of Trypanosoma cruzi reveals hybridization and clonal mechanisms driving rapid genome diversification

GM Matos, MD Lewis, C Talavera-López, M Yeo… - Elife, 2022 - elifesciences.org
Protozoa and fungi are known to have extraordinarily diverse mechanisms of genetic
exchange. However, the presence and epidemiological relevance of genetic exchange in …