Over the past decade, a large body of evidence has emerged demonstrating an integration
of metabolic and immune response pathways. It is now clear that obesity and associated …

The link between inflammation and the development of insulin resistance, type 2 diabetes,
and atherosclerosis has been uncovered in the past decade. Although the molecular …

Adipose tissue inflammation is a characteristic of obesity. However, the mechanisms that
regulate this inflammatory response and link adipose inflammation to systemic metabolic …

Over the past decade, evidences of an integration of metabolic and inflammatory pathways,
referred to as metaflammation in several aspects of metabolic syndrome, have been …

Macrophages are almost everywhere in the body, where they serve pivotal functions in
maintaining tissue homeostasis, remodeling, and immunoregulation. Macrophages are …

Hypothalamic inflammation contributes to metabolic dysregulation and the onset of obesity.
Dietary saturated fats activate microglia via a nuclear factor-kappa B (NFκB) mediated …

Lipids are vital components of many biological processes and crucial in the pathogenesis of
numerous common diseases, but the specific mechanisms coupling intracellular lipids to …

Fatty acid binding proteins (FABPs) are members of a highly conserved family of proteins
with the task of protecting a cell's delicate lipid balance. Yet they fail when faced with …

Fatty acid binding proteins (FABPs) are cytosolic fatty acid chaperones whose biological role
and mechanisms of action are not well understood. Here, we developed mice with targeted …

Intracellular and extracellular interactions with proteins enables the functional and
mechanistic diversity of lipids. Fatty acid-binding proteins (FABPs) were originally described …