Progressive tissue necrosis is a process unique to the injured mammalian spinal cord which
often leads to gradually increasing cavitation and enlargement of the lesion. To evaluate the …

Reactive changes in macrophages/microglia and astrocytes were evaluated following spinal
cord injury in normal mice of the C57BL/6J strain and in mice carrying a mutation (Wlds) …

Various inbred strains of mice exhibit dramatic differences in sensitivity to excitotoxic cell
death induced by systemic injections of kainic acid (KA). The present study evaluates …

Partial lesions of the mammalian spinal cord result in an immediate motor impairment that
recovers gradually over time; however, the cellular mechanisms responsible for the transient …

Tissue destruction at the primary site of a spinal cord injury leads to persistent necrosis that
progressively enlarges the lesion. Steroids attenuate this necrotizing process and promote …

The presence of an adequate blood supply is a critical factor in recovery from traumatic
injuries. We have examined whether the revascularization of the injured tissues is as crucial …

Models of spinal cord injury (SCI) have been developed over the years in order to study
different aspects of recovery of function, the biology of injury, regeneration, and therapeutics …

Mice display a wound healing process after spinal cord injury that has not been seen in any
other species. Rather than exhibiting progressive necrosis and cavitation at the injury site …

There exists a trend for a better functional recovery from spinal cord injury (SCI) in younger
patients compared to adults, which is also reported for animal studies; however, the reasons …

This study examines the relationship between the appearance of degenerative changes in
synaptic terminals and axons and the activation of microglia in denervated neuropil regions …