Aims To investigate whether the relative amounts of fat, carbohydrate (CHO), or protein in a
meal influence the pharmacokinetics of a small dose of ethanol. Methods Nine healthy men …

The effect of the concentration of ingested ethanol on the resulting blood alcohol
concentrations (BAC) was tested in both humans and rats. In humans, when 0.3 g/kg body …

The area under blood ethanol concentration-time curves may be lower after ingestion vs.
intravenous infusion of similar ethanol doses, a difference that has been attributed to first …

1. The magnitude of the variability of ethanol absorption is an important factor for studies that
seek to determine the significance of potential interactions between ethanol and drugs. The …

Whole capillary blood ethanol concentrations following the oral administration of a 30-ml
dose of absolute alcohol (0.32 g/kg absolute alcohol) and 45-ml doses of 95% alcohol (0.45 …

THE ABSORPTION, DISTRIBUTION, and elimination of ethanol in humans were studied by
Erik MP Widmark (1889–1945) during the first decades of the 20th century (Andreasson and …

1 To compare classical linear regression techniques and a Michaelis‐Menten elimination
model eight normal human volunteers each received three intravenous doses (0.375, 0.5 …

1. Twelve healthy men drank 0.80 g ethanol kg‐1 body weight on four occasions spread
over several weeks. Ethanol was given as 96% v/v solvent which was diluted with orange …

The pharmacokinetics of ethanol after typical doses are described by a 1-compartment
model with concentration-dependent elimination. The volume of distribution estimated from …

Objective To assess the extent and site of the first‐pass metabolism of ethanol and to
examine whether first‐pass metabolism and disposition of ethanol are dependent on …