Therapies modulating the immune system offer the prospect of treating a wide range of
conditions including infectious diseases, cancer and autoimmunity. Biomaterials can …

Conspectus A major function of the immune system is to detect threat from foreign invaders,
tissue damage, or cancer and to mount a counter response that resolves the threat, restores …

Solid organ transplant (SOT) recipients require meticulously tailored immunosuppressive
regimens to minimize graft loss and mortality. Traditional approaches focus on inhibiting …

The immune system has evolved to recognize and eliminate pathogens; this recognition
relies on the identification of structural molecular patterns within unique tissue …

Recent research in the vaccine and immunotherapy fields has revealed that biomaterials
have the ability to activate immune pathways, even in the absence of other immune …

Small alterations during early stages of innate immune response can drive large changes in
how adaptive immune cells develop and function during protective immunity or disease …

Advances in allogeneic transplantation of solid organs and tissues depend on our
understanding of mechanisms that mediate the prevention of graft rejection. For the past …

Introduction Cell transplantation is a promising curative therapeutic strategy whereby
impaired organ function can be restored without the need for whole-organ transplantation. A …

A cure for type 1 diabetes (T1D) would help millions of people worldwide but remains
elusive to date. Tolerogenic vaccines and β-cell replacement therapy are complementary …

Objectives Biomaterials are routinely used in clinical applications. A key to the clinical
success of implanted biomaterials is not eliciting detrimental immune responses. In this …