Background β-Amyloid peptide (Aβ) is a major protein in the brain associated with
Alzheimer's and Parkinson's diseases. The purpose of this study was to investigate the role …

The crosstalk between the nervous and immune systems has gained increasing attention for
its emerging role in neurological diseases. Radiation-induced brain injury (RIBI) remains the …

Alzheimer's disease (AD) is one of the most prominent neurodegenerative diseases, which
impairs cognitive function in afflicted individuals. AD results in gradual decay of neuronal …

Microglia are strongly implicated in the development and progression of Alzheimer's disease
(AD), yet their impact on pathology and lifespan remains unclear. Here we utilize a CSF1R …

Microglial cells consume adenosine triphosphate (ATP) during phagocytosis to clear
neurotoxic β-amyloid in Alzheimer's disease (AD). However, the contribution of energy …

Background: Alzheimer's disease (AD) is a complex neurodegenerative disorder
characterized by the progressive loss of neurons, which typically leads to severe …

In the contexts of aging, injury, or neuroinflammation, activated microglia signaling with TNF-
α, IL-1α, and C1q induces a neurotoxic astrocytic phenotype, classified as A1, A1-like, or …

Astrocytes, an integral component of the central nervous system (CNS), contribute to the
maintenance of physiological homeostasis through their roles in synaptic function, K+ …

Microglia are brain immune cells that constantly survey their environment to maintain
homeostasis. Enhanced microglial reactivity and proliferation are typical hallmarks of …

Microglia, the resident immune cells of the mammalian central nervous system (CNS), play a
pivotal role in both physiological and pathological conditions such as the restoration of CNS …