Crosstalk between the mTOR and Nrf2/ARE signaling pathways as a target in the improvement of long-term potentiation
In recent years, a significant progress was made in understanding molecular mechanisms of
long-term memory. Long-term memory formation requires strengthening of neuronal …
long-term memory. Long-term memory formation requires strengthening of neuronal …
Dysregulation of the mTOR pathway mediates impairment of synaptic plasticity in a mouse model of Alzheimer's disease
Background The mammalian target of rapamycin (mTOR) is an evolutionarily conserved
Ser/Thr protein kinase that plays a pivotal role in multiple fundamental biological processes …
Ser/Thr protein kinase that plays a pivotal role in multiple fundamental biological processes …
The Interaction of mTOR and Nrf2 in Neurogenesis and Its Implication in Neurodegenerative Diseases
Neurogenesis occurs in the brain during embryonic development and throughout adulthood.
Neurogenesis occurs in the hippocampus and under normal conditions and persists in two …
Neurogenesis occurs in the hippocampus and under normal conditions and persists in two …
mTOR signaling as a molecular target for the alleviation of Alzheimer's disease pathogenesis
Mechanistic/mammalian target of rapamycin (mTOR) belongs to the phosphatidylinositol
kinase-related kinase (PIKK) family. mTOR signaling is required for the commencement of …
kinase-related kinase (PIKK) family. mTOR signaling is required for the commencement of …
Targeting the mTOR signaling network for Alzheimer's disease therapy
C Wang, JT Yu, D Miao, ZC Wu, MS Tan, L Tan - Molecular neurobiology, 2014 - Springer
The mammalian target of rapamycin (mTOR) is a highly conserved serine/threonine kinase
that can sense environmental stimuli such as growth factors, energy state, and nutrients. It is …
that can sense environmental stimuli such as growth factors, energy state, and nutrients. It is …
mTOR in Alzheimer disease and its earlier stages: Links to oxidative damage in the progression of this dementing disorder
Alzheimer's disease (AD) is the most prevalent form of dementia in the elderly population
and has worldwide impact. The etiology of the disease is complex and results from the …
and has worldwide impact. The etiology of the disease is complex and results from the …
mTOR signaling in aging and neurodegeneration: at the crossroad between metabolism dysfunction and impairment of autophagy
M Perluigi, F Di Domenico, DA Butterfield - Neurobiology of disease, 2015 - Elsevier
Compelling evidence indicates that the mammalian target of rapamycin (mTOR) signaling
pathway is involved in cellular senescence, organismal aging and age-dependent diseases …
pathway is involved in cellular senescence, organismal aging and age-dependent diseases …
Targeting mTOR to reduce Alzheimer-related cognitive decline: from current hits to future therapies
A Tramutola, C Lanzillotta… - Expert Review of …, 2017 - Taylor & Francis
Introduction: The mTOR pathway is involved in the regulation of a wide repertoire of cellular
functions in the brain and its dysregulation is emerging as a leitmotif in a large number of …
functions in the brain and its dysregulation is emerging as a leitmotif in a large number of …
Activation of mTOR: a culprit of Alzheimer's disease?
Z Cai, G Chen, W He, M Xiao, LJ Yan - … disease and treatment, 2015 - Taylor & Francis
Alzheimer's disease (AD) is characterized by cognitive impairment in clinical presentation,
and by β-amyloid (Aβ) production and the hyper-phosphorylation of tau in basic research …
and by β-amyloid (Aβ) production and the hyper-phosphorylation of tau in basic research …
mTOR‐dependent signalling in Alzheimer's disease
JJ Pei, J Hugon - Journal of cellular and molecular medicine, 2008 - Wiley Online Library
• Introduction• Neurodegeneration and neurofibrillary degeneration in Alzheimer's disease
brains• Dysfunction of protein synthesis mediated by mTOR‐dependent signalling in …
brains• Dysfunction of protein synthesis mediated by mTOR‐dependent signalling in …